Results 31 to 40 of about 1,736,990 (170)

Matrix metalloproteinases and their inhibitors in canine mammary tumors [PDF]

BMC Veterinary Research, 2011
Malignant canine mammary tumors represent 50% of all neoplasms in female dogs. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are thought to be involved in tumor progression, and they are also associated with the reactive stroma, which provides structural and vascular support for tumor growth.MMP-2, MMP-9 and MT1 ...
ARESU, LUCA, GIANTIN, MERY, MORELLO E, VASCELLARI M, CASTAGNARO, MASSIMO, LOPPARELLI, ROSA MARIA, ZANCANELLA, VANESSA, GRANATO A, GARBISA, SPIRIDIONE, ARICO', ARIANNA, BRADASCHIA A, MUTINELLI F, DACASTO, MAURO   +12 more
openaire   +5 more sources

Microvessel density assessment in canine mammary carcinomas as a predictive factor for metronomic chemotherapy

Semina: Ciências Agrárias, 2019
The canine mammary tumor is the neoplasia that most commonly affects intact female dogs (not spayed) in routine veterinary practice. Canine mammary tumor therapy is a challenge because only few effective treatments have been described for high-grade ...
Analy Ramos Mendes Ferrari, Heitor Flavio Ferrari, Vinicius Soares Carreira, Edenilson Doná Frigério, Maria Cecília Rui Luvizotto, Alexandre Lima de Andrade   +5 more
doaj   +1 more source

Microsatellite Instability in Canine Mammary Gland Tumors [PDF]

Journal of Veterinary Internal Medicine, 2007
Abstract Background: Genomic instability is a hallmark of cancer and may be required for the accumulation of cancer-causing mutations within cells. One form of genomic instability occurs in tandem nucleotide repeats and is known as microsatellite instability (MSI). Hypothesis: We hypothesized that MSI can be observed
Elizabeth A, McNiel, Kelly L, Griffin, Amelia M, Mellett, Nicole J, Madrill, James R, Mickelson   +4 more
openaire   +2 more sources

Significance of EZH2 expression in canine mammary tumors [PDF]

BMC Veterinary Research, 2016
Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits of Polycomb repressive complex 2, a crucial epigenetic regulator. EZH2 has a master regulatory function in such processes as cell proliferation,
Choi, Hyun-Ji, Jang, Sungwoong, Ryu, Jae-Eun, Lee, Hyo-Ju, Lee, Han-Byul, Ahn, Woo-Sung, Kim, Hye-Jin, Lee, Hyo-Jin, Lee, Hee Jin, Gong, Gyung-Yub, Son, Woo-Chan   +10 more
openaire   +3 more sources

E-Cadherin Immunoreactivity in Canine Mammary Tumors [PDF]

Journal of Veterinary Diagnostic Investigation, 2004
The reduction or loss of E-cadherin (E-cad), a calcium-dependent epithelial cell adhesion molecule, has been associated with tumor dedifferentiation and invasiveness. The immunohistochemical pattern of E-cad expression was evaluated in formalin-fixed and paraffin-embedded sections of 6 normal mammary glands, 3 dysplasias, 12 benign tumors (8 benign ...
Giuseppe, Sarli, Rosario, Preziosi, Louis, De Tolla, Barbara, Brunetti, Cinzia, Benazzi   +4 more
openaire   +2 more sources

Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs

Breast Cancer Research, 2023
Background About 20% of breast cancers in humans are basal-like, a subtype that is often triple-negative and difficult to treat. An effective translational model for basal-like breast cancer is currently lacking and urgently needed.
Joshua Watson, Tianfang Wang, Kun-Lin Ho, Yuan Feng, Tanakamol Mahawan, Kevin K. Dobbin, Shaying Zhao   +6 more
doaj   +1 more source

Canine Mammary Tumours - Clinical Survey [PDF]

Macedonian Veterinary Review, 2014
Abstract Mammary tumours are the second most frequent neoplasia in dogs, mainly affecting older female patients. Approximately 50% of the mammary tumours are malignant with high percentage of mortality, if not treated in time. The aim of this study was to analyze the data of canine patients with mammary tumours, to evaluate the type of ...
Elena Atanaskova Petrov, Ksenija Ilievska, Plamen Trojacanec, Irena Celeska, Goran Nikolovski, Ivica Gjurovski, Toni Dovenski   +6 more
openaire   +2 more sources

Preclinical Evaluation of the Oncolytic Vaccinia Virus TG6002 by Translational Research on Canine Breast Cancer

Molecular Therapy: Oncolytics, 2020
Oncolytic virotherapy is a promising therapeutic approach for the treatment of cancer. TG6002 is a recombinant oncolytic vaccinia virus deleted in the thymidine kinase and ribonucleotide reductase genes and armed with the suicide gene FCU1, which encodes
Jérémy Béguin, Johann Foloppe, Christelle Maurey, Eve Laloy, Julie Hortelano, Virginie Nourtier, Christelle Pichon, Sandrine Cochin, Pascale Cordier, Hélène Huet, Eric Quemeneur, Bernard Klonjkowski, Philippe Erbs   +12 more
doaj   +1 more source

Upregulation of SLUG expression in canine mammary gland tumors and its prognostic significance

BMC Veterinary Research, 2023
Background SLUG (also known as snai2), which is a transcription factor in epithelial–mesenchymal transition (EMT), plays an important role in tumorigenesis.
Soo-Bin Cheon, Wan Hee Kim
doaj   +1 more source

Lymph Drainage of the Mammary Glands in Female Cats [PDF]

, 2006
The mammary gland is a common site of neoplasms in the female cat. All the malignant tumors metastasize to a lesser or a greater extent through the lymphatic system.
Sautet, Jean, Raharison, Fidiniaina
core   +1 more source