Neuroprotective Effect of Cannabidiol Against Rotenone in Hippocampal Neuron Culture
Chemistry – An Asian Journal, EarlyView.(–)‐Cannabidiol (CBD) protects primary hippocampal neurons from rotenone, a mitochondrial complex I inhibitor that causes cell death. CBD preserves neuronal viability and morphology, with antagonist assays showing that transient receptor potential vanilloid 1 (TRPV1) mediates this neuroprotective effect.
Seoin Yang +3 more
openalex +2 more sources
Combination therapy with cannabidiol and chemotherapeutics in canine urothelial carcinoma cells.
PLoS ONE, 2021 BackgroundCanine urothelial carcinoma is the most common form of canine bladder cancer. Treatment with chemotherapy has variable response rates leading to most dogs succumbing to their disease within a year.
Jordon M Inkol +2 more
doaj +2 more sources
CANNABIDIOL- PROVOKES OR TREATS ANXIETY DISORDERS?
European Psychiatry, 2023 Introduction After the introduction of proposal regarding cannabidiol for the treatment of some psychiatric disorders including anxiety, there is confusion if cannabidiol use is associated with the provocation of anxiety symptoms or it can be safely ...
H. Arshad +5 more
doaj +1 more source
Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. [PDF]
PLoS ONE, 2014 Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content.
João W Silveira +7 more
doaj +1 more source
The antimicrobial potential of cannabidiol
Communications Biology, 2021 Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae.
Mark A. T. Blaskovich +21 more
doaj +1 more source
Cannabidiol markedly alleviates skin and liver fibrosis
Frontiers in Pharmacology, 2022 Cannabidiol (CBD) has been suggested as a potential therapy for inflammatory and fibrotic diseases. Cannabidiol was demonstrated to reduce alcohol-induced liver inflammation and steatosis but its specific activity on the fibrotic process was not ...
Carmen del Río +12 more
doaj +1 more source
Cannabidiol stimulates AML-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner [PDF]
, 2015 Glioma stem-like cells (GSCs) correspond to a tumor cell subpopulation, involved in glioblastoma multiforme (GBM) tumor ini- tiation and acquired chemoresistance.
Amantini, Consuelo +7 more
core +2 more sources
The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects [PDF]
, 2015 Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells.
Cascio, Maria Grazia +4 more
core +1 more source
Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study [PDF]
, 2008 <b>Objective</b>: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain.
Frank, B. +4 more
core +2 more sources
Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ
Journal of Immunology Research, 2020 Innate lymphoid cells (ILCs) have emerged as largely tissue-resident archetypal cells of the immune system. We tested the hypotheses that renal ischemia-reperfusion injury (IRI) is a contributing factor to polarization of ILCs and that glucocorticoid ...
Babak Baban +5 more
doaj +1 more source