Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]
Frontiers in Pharmacology, 2014 Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy model of depression with ...
Petra eAmchova +19 more
doaj +3 more sources
Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals
Pharmacology, 2022 Background: There is a growing interest in the use of cannabis (and its extracts), as well as CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes.
Christopher A. Legare +2 more
semanticscholar +1 more source
Semiquantitative activity-based detection of JWH-018, a synthetic cannabinoid receptor agonist, in oral fluid after vaping [PDF]
, 2020 The rapid proliferation of new synthetic cannabinoid receptor agonists (SCRAs) has initiated considerable interest in the development of so-called “untargeted” screening strategies.
Cannaert, Annelies +5 more
core +2 more sources
Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain
Drugs, 2021 The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in recent decades and a growing body of evidence suggests that phytocannabinoids are beneficial for a range of conditions.
B. Stella +5 more
semanticscholar +1 more source
Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]
, 2012 BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen +8 more
core +11 more sources
Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity
Scientific Reports, 2021 Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby they modulate cannabinoids to result in improved outcomes.
J. LaVigne +3 more
semanticscholar +1 more source
Harm Reduction Journal, 2020 Background In 2016, the Australian federal government passed legislation enabling a range of cannabis-based products to be prescribed to patients by registered healthcare professionals.
Nicholas Lintzeris +7 more
doaj +1 more source
Drug Metabolism And Disposition, 2021 The legalization of cannabis in many parts of the United States and other countries has led to a need for a more comprehensive understanding of cannabis constituents and their potential for drug-drug interactions.
Shamema Nasrin +3 more
semanticscholar +1 more source
Journal of Cannabis Research, 2023 Road safety is an important concern amidst expanding worldwide access to legal cannabis. The present study reports on the driving-related subsection of the Cannabis as Medicine Survey 2020 (CAMS-20) which surveyed driving-related behaviors, attitudes ...
Thomas R. Arkell +6 more
doaj +1 more source
Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases
International Journal of Molecular Sciences, 2023 We report enzymes from the berberine bridge enzyme (BBE) superfamily that catalyze the oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA) to form cannabielsoin (CBE). The enzymes are from a variety of organisms and are previously uncharacterized.
Maybelle Kho Go +6 more
openaire +2 more sources