Results 11 to 20 of about 91,153 (299)
Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]
Frontiers in Pharmacology, 2014 Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy model of depression with ...
Petra eAmchova +19 more
doaj +3 more sources
Semiquantitative activity-based detection of JWH-018, a synthetic cannabinoid receptor agonist, in oral fluid after vaping [PDF]
, 2020 The rapid proliferation of new synthetic cannabinoid receptor agonists (SCRAs) has initiated considerable interest in the development of so-called “untargeted” screening strategies.
Cannaert, Annelies +5 more
core +2 more sources
Journal of Cannabis Research, 2023 Road safety is an important concern amidst expanding worldwide access to legal cannabis. The present study reports on the driving-related subsection of the Cannabis as Medicine Survey 2020 (CAMS-20) which surveyed driving-related behaviors, attitudes ...
Thomas R. Arkell +6 more
doaj +1 more source
Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases
International Journal of Molecular Sciences, 2023 We report enzymes from the berberine bridge enzyme (BBE) superfamily that catalyze the oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA) to form cannabielsoin (CBE). The enzymes are from a variety of organisms and are previously uncharacterized.
Maybelle Kho Go +6 more
openaire +2 more sources
Asian Journal of Pharmaceutical Research and Health Care, 2022 Cannabidiol industrialization is expected to reach $20 billion in sales by 2024 due to a sudden rise in scientific interest in marijuana (cannabis) and its therapeutic potential. Cannabis has been utilized for thousands of years in both medicine and science.
Nicholas T. Lappas, Courtney M. Lappas
+4 more sources
BMC Pediatrics, 2018 Background Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the frequency of convulsive seizures and lead to improvements in quality of life in children affected by epileptic encephalopathies.
Darren Reithmeier +14 more
doaj +1 more source
Frontiers in Psychiatry, 2022 IntroductionSynthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances that have been associated with multiple instances and types of toxicity. Some SCRAs appear to carry a greater toxicological burden than others,
Richard C. Kevin +13 more
doaj +1 more source
Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]
, 2012 BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen +8 more
core +7 more sources
Cannabinoid Hyperemesis Syndrome [PDF]
, 2015 Legalization of marijuana use will increase the number of people who will become long-term users. A prior medical record review study in Australia, in 2004, identified 19 chronic marijuana users who entered the emergency department with recurrent ...
Heise, Lynn
core +2 more sources
The evolution and comparative neurobiology of endocannabinoid signalling [PDF]
, 2012 CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A. +4 more
core +1 more source