Results 1 to 10 of about 2,668,334 (282)
Cannabinoids and Cannabinoid Receptors: The Story so Far [PDF]
iScience, 2020 Like most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case, between the cannabinoids and their putative targets, the G-protein coupled receptors (GPCRs) cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).
Fred Shahbazi +3 more
openaire +4 more sources
Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes
Chemistry and Physics of Lipids, 2002 Delta(9)-Tetrahydrocannabinol (delta(9)-THC), the primary psychoactive constituent of marijuana (Cannabis sativa), is known to bind to two cannabinoid receptors: CB(1) receptors, located primarily in the brain, and CB(2) receptors, located primarily in the periphery.
Jenny L, Wiley, Billy R, Martin
openaire +3 more sources
Current Biology, 2002 Abstract Cannabinoid receptors are seven transmembrane receptors that mediate the central and peripheral actions of extracts from the cannabis plant. Although many endogenous agonists of cannabinoid receptors have been described, a categorical role of these (mainly fatty acid derived) molecules as the endogenous ligand for cannabinoid ...
D A Kendall, S P H Alexander
+5 more sources
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.
Cell, 2020 Human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors CB1 and CB2. Their high sequence similarity, low agonist selectivity, and lack of activation and G protein-coupling knowledge ...
T. Hua +22 more
semanticscholar +1 more source
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 2019 Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor 1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl cyclase-inhibiting heterotrimeric G protein Gi.
Kaavya Krishna Kumar +15 more
semanticscholar +1 more source
Crystal Structure of the Human Cannabinoid Receptor CB2.
Cell, 2019 The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in inflammatory, fibrotic, and neurodegenerative diseases.
Xiaoting Li +23 more
semanticscholar +1 more source
Novel cannabinoid receptors [PDF]
British Journal of Pharmacology, 2007 Cannabinoids have numerous physiological effects. In the years since the molecular identification of the G protein‐coupled receptors CB1 and CB2, the ion channel TRPV1, and their corresponding endogenous ligand systems, many cannabinoid‐evoked actions have been shown conclusively to be mediated by one of these specific receptor targets.
openaire +2 more sources
Nature Communications, 2018 Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon
W. Xiang +22 more
semanticscholar +1 more source
Brain cannabinoid receptor 2: expression, function and modulation
Acta Pharmacologica Sinica, 2017 Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of molecules, some with psychoactive effects. At least 4% of the world's adult population uses cannabis annually, making it one of the most frequently used illicit
De-jie Chen +4 more
semanticscholar +1 more source
Progress in brain cannabinoid CB2 receptor research: From genes to behavior
Neuroscience and Biobehavioral Reviews, 2019 HighlightsCannabinoid CB2R was initially assumed to be exclusively in the periphery.Technological innovations have revealed functional CB2R expression in neurons.Species differences exist in CB2R genes, receptor expression, and function.Region‐specific ...
C. Jordan, Z. Xi
semanticscholar +1 more source