Results 31 to 40 of about 41,551 (306)

Opioid and cannabinoid receptors

Current Opinion in Neurobiology, 1994
Opioids and cannabinoids are two major classes of drugs with important clinical uses as well as significant side effects. Recently, the three major subtypes of opioid receptors, delta, kappa and mu, have been cloned. Both the endogenous cannabinoids and their receptors have also recently been cloned.
T, Reisine, M J, Brownstein
openaire   +2 more sources

Novel putative ligands of cannabinoid receptors: synthesis and effects on cell signaling and neuronal functions [PDF]

The Ukrainian Biochemical Journal, 2023
Cannabinoid ligands are known to possess neuroprotective actions and may have utility in the treatment of neurodegeneration. The major targets for cannabinoids include the classical CB1 cannabinoid receptor, as well as the novel cannabinoid receptor ...
J. Senkiv, A. Kryshchyshyn-Dylevych, D. Khylyuk, M. Wujec, R. Stoika, A. J. Irving, R. Lesyk   +6 more
doaj   +1 more source

Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells.

PLoS ONE, 2008
BackgroundWhile cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown.Methodology/principal findingsThe activity of the endocannabinoid system was evaluated in ...
Christoph W Michalski, Milena Maier, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Nathalia A Giese, Thomas Giese, Helmut Friess, Jörg Kleeff   +10 more
doaj   +1 more source

Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism

, 2020
The manuscript of a paper entitled "Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism".
Anton, Bashilov, Sergei, Gavryushov, Nikolay, Kuzmich, Boris, Izotov, Konstantin, Cherashev-Tumanov, Tatyana, Burykina   +5 more
core   +1 more source

Psychosocial stress and cannabinoid drugs affect acetylation of α-tubulin (K40) and gene expression in the prefrontal cortex of adult mice

PLoS ONE, 2022
The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated ...
Jordi Tomas-Roig, Shyam Ramasamy, Diana Zbarsky, Ursula Havemann-Reinecke, Sigrid Hoyer-Fender   +4 more
doaj   +2 more sources

THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior

Scientific Reports, 2021
High doses of the Cannabis constituent Δ9-tetrahydrocannabinol (THC) increase the risk of psychosis in humans. Highly accessible animal models are needed to address underlying mechanisms.
Amelia Dahlén, Mahdi Zarei, Adam Melgoza, Mahendra Wagle, Su Guo   +4 more
doaj   +1 more source

Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. [PDF]

PLoS ONE, 2007
Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate.
Shuxian Jiang, Yigong Fu, John Williams, Jodianne Wood, Lakshmipathi Pandarinathan, Shiri Avraham, Alexandros Makriyannis, Shalom Avraham, Hava Karsenty Avraham   +8 more
doaj   +1 more source

Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors. [PDF]

PLoS ONE, 2012
The cannabinoid system is known to be involved in the regulation of inflammatory processes. Therefore, drugs targeting cannabinoid receptors are considered as candidates for anti-inflammatory and tissue protective therapy.
Svantje Tauber, Katrin Paulsen, Susanne Wolf, Peggy Synwoldt, Andreas Pahl, Regine Schneider-Stock, Oliver Ullrich   +6 more
doaj   +1 more source

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections [PDF]

, 2012
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Natsuo Ueda, Ueda Natsuo, Dehghani Faramarz, Faramarz Dehghani (109822), Hobusch Constance, Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Koch Marco, Geisslinger Gerd, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Natsuo Ueda (176896), Constance Hobusch, Kallendrusch Sonja, Ehrlich Angela, Kallendrusch, Sonja, Ueda, Natsuo, Marco Koch, Angela Ehrlich (109799)   +31 more
core   +1 more source

Signaling through the type 2 cannabinoid receptor regulates the severity of acute and chronic graft-versus-host disease. [PDF]

, 2021
Graft versus host disease (GVHD) pathophysiology is a complex interplay between cells that comprise the adaptive and innate arms of the immune system. Effective prophylactic strategies are therefore contingent upon approaches that address contributions
Romero, Julián, Drobyski, William R., Yuan, Cheng-Yin, Komorowski, Richard, Tolón, Rosa María, Stollenwerk, Todd, Sauber, Garrett, López, Alicia, Zhou, Vivian, Hillard, Cecilia J.   +9 more
core   +1 more source