Results 51 to 60 of about 41,551 (306)

The development and therapeutic potential of classical and next-generation cannabinoid ligands

Pharmacological Research
The endogenous cannabinoid system (ECS) is a complex network that plays a crucial role in various physiological processes, and its modulation through cannabinoid ligands has garnered significant interest in pharmacological research. Cannabinoid receptors,
Verónica Muñoz-Canales, Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, Silvia Ortega-Gutiérrez   +4 more
doaj   +1 more source

The role of cannabinoid agonists and antagonists on folliculogenesis and evolutionary events in the mouse ovary [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Cannabinoids, derivatives of Cannabis sativa L., can activate the endocannabinoid system via two endogenous receptors, CB1 and CB2. This system is crucial in regulating folliculogenesis, fertility, and reproductive function.
Vida Mirzaie, Touba Eslaminejad, Fatemeh Sheikhbahaei, Shayan Vafaei, Fatemeh Nabipour, Mina Behzadi, Seyyed Noureddin Nematollahi-Mahani   +6 more
doaj   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X, Jiang, Y, Karteris, E, Bai, B, Chen, J, Karteris, Emmanouil, Bai, Bo, Jiang, Yunlu, Cai, Xin, Chen, Jing   +9 more
core   +1 more source

Axially Chiral Cannabinoids: Design, Synthesis, and Cannabinoid Receptor Affinity

, 2023
The resorcinol-terpene phytocannabinoid template is a privileged scaffold for the development of diverse therapeutics target-ing the endocannabinoid system. Axially chiral cannabinols (axCBNs) are unnatural cannabinols (CBNs) that bear an addi-tional C10
Sara , Kearney, Christopher, Cunningham, Thomas, Gamage, Terry-Elinor, Reid, Alexander, Grenning, Daniel, Barrus, Anghelo, Gangano, Adrian, Roitberg, Primali, Navaratne, Kyle, Rehrauer, Ion, Ghiviriga   +10 more
core   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?

Pharmaceutics, 2021
The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine.
Leontina Elena Filipiuc, Daniela Carmen Ababei, Teodora Alexa-Stratulat, Cosmin Vasilica Pricope, Veronica Bild, Raluca Stefanescu, Gabriela Dumitrita Stanciu, Bogdan-Ionel Tamba   +7 more
doaj   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Cannabinoids and Their Receptors in Skin Diseases

International Journal of Molecular Sciences, 2023
The therapeutic application of cannabinoids has gained traction in recent years. Cannabinoids interact with the human endocannabinoid system in the skin. A large body of research indicates that cannabinoids could hold promise for the treatment of eczema, psoriasis, acne, pruritus, hair disorders, and skin cancer. However, most of the available data are
Eun Hee Yoo, Ji Hyun Lee
openaire   +2 more sources

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
Silvia Cianci, ROMANO, ADELE, Romano, A, M. r. Elphick, Gianluigi Vendemiale, Pace, Lorenzo, Elphick, Maurice R, Bedse, G, Angelo M. Lavecchia, Gaurav Bedse, GAETANI, SILVANA, VENDEMIALE, GIANLUIGI, LAVECCHIA, ANGELO MICHELE, @CORRESPONDING AUTHOR, Vendemiale, G, CIANCI, SILVIA, Pace Lorenzo, Lorenzo Federico Pace, Adele Romano, Gaetani, S, Tommaso Cassano, BEDSE, GAURAV, Lorenzo, P, Caterina Grillo, Cassano, T, Grillo, C, Laferla, Frank M, ALTIERI, Fabio, Elphick, MR, LaFerla, FM, Maurice R. Elphick, GRILLO, CATERINA, Silvana Gaetani, Frank M. LaFerla, F. m. Laferla, CASSANO, TOMMASO, Lavecchia, AM, Fabio Altieri, Altieri, F, Cianci, S   +39 more
core   +1 more source