Results 21 to 30 of about 65,361 (277)

Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]

, 2014
Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with ...
Amchova P, Babinska Z, Dusek L, FADDA, PAOLA, Fattore L., FRATTA, WALTER, Giugliano V, Kucerova J, Micale V, SCHERMA, MARIA, Sulcova A, ZANDA, MARY TRESA   +11 more
core   +1 more source

Novel cannabinoid receptors [PDF]

British Journal of Pharmacology, 2007
Cannabinoids have numerous physiological effects. In the years since the molecular identification of the G protein‐coupled receptors CB1 and CB2, the ion channel TRPV1, and their corresponding endogenous ligand systems, many cannabinoid‐evoked actions have been shown conclusively to be mediated by one of these specific receptor targets.
openaire   +2 more sources

Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain

Molecular Pain, 2017
The cannabinoid 1 receptor and cannabinoid 2 receptor can both be targeted in the treatment of pain; yet, they have some important differences. Cannabinoid 1 receptor is expressed at high levels in the central nervous system, whereas cannabinoid 2 ...
Matthew B Yuill, David E Hale, Josée Guindon, Daniel J Morgan   +3 more
doaj   +1 more source

Semiquantitative activity-based detection of JWH-018, a synthetic cannabinoid receptor agonist, in oral fluid after vaping [PDF]

, 2020
The rapid proliferation of new synthetic cannabinoid receptor agonists (SCRAs) has initiated considerable interest in the development of so-called “untargeted” screening strategies.
Cannaert, Annelies, Fernandez, Maria del Mar Ramirez, Ramaekers, Johannes G., Stove, Christophe, Theunissen, Eef L., Wille, Sarah   +5 more
core   +2 more sources

Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]

, 2019
CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P., Dvorácskó, Szabolcs, MINOSI, PAOLA, MOLLICA, Adriano, PIERETTI, Stefano, Stefanucci, Azzurra, Tömböly, Csaba, Zengin, Gokhan   +7 more
core   +2 more sources

Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells.

PLoS ONE, 2008
BackgroundWhile cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown.Methodology/principal findingsThe activity of the endocannabinoid system was evaluated in ...
Christoph W Michalski, Milena Maier, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Nathalia A Giese, Thomas Giese, Helmut Friess, Jörg Kleeff   +10 more
doaj   +1 more source

Psychosocial stress and cannabinoid drugs affect acetylation of α-tubulin (K40) and gene expression in the prefrontal cortex of adult mice

PLoS ONE, 2022
The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated ...
Jordi Tomas-Roig, Shyam Ramasamy, Diana Zbarsky, Ursula Havemann-Reinecke, Sigrid Hoyer-Fender   +4 more
doaj   +2 more sources

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
Adams, Agrawal, Ahern, Alger, Armstrong, Arnone, Avraham, Bachur, Baker, Baker, Barbano, Basavarajappa, Basavarajappa, Ben Amar, Ben-Zvi, Berridge, Berridge, Bisogno, Blankman, Bortolato, Breivogel, Brown, Brown, Burkey, Cadas, Cahn, Chan, Childers, Clark, Comelli, Consroe, Costiniuk, Cota, Cota, Cota, Cravatt, Davis, Davis, De Filippis, De Petrocellis, De Petrocellis, Deadwyler, Dennis, Deutsch, Devane, Devane, Dewey, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Elmquist, Engeli, Evans, Fadda, Farrimond, Farrimond, Felder, Fong, Fonseca, Fredriksson, Freund, Gaetani, Gallate, Gaoni, Gaoni, Gaoni, Gardner, Gatley, Gerdeman, Gill, Glass, Glick, Gomez, Gong, Goutopoulos, Grant, Hao, Henstridge, Henstridge, Herkenham, Herkenham, Higgs, Hohmann, Holland, Hollister, Horswill, Hosohata, Howlett, Howlett, Howlett, Huffman, Hughes, Ishiguro, Izzo, Jamshidi, Jarrett, Jarrett, Jin, Kapur, King, Kirby, Kirkham, Kirkham, Kirkham, Kirkham, Kirkham, Koch, Lambert, Landsman, Lauckner, Lauckner, Ligresti, Little, Liu, Long, Ma, Maccarrone, Maccarrone, Mackie, Mackie, Makriyannis, Martin, Mathes, Matsuda, Mechoulam, Mechoulam, Moldrich, Morgan, Morley, Munro, Naidu, Ning, Ohno-Shosaku, Okamoto, Okamoto, Okamoto, Onaivi, Onaivi, Onaivi, Osei-Hyiaman, Overton, Overton, Oz, Pacheco, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Petitet, Petrosino, Pietr, Piomelli, Piomelli, Piomelli, Pope, Pryce, Pryce, Putney, Rao, Riedel, Rinaldi-Carmona, Rinaldi-Carmona, Rodriguez de Fonseca, Ronesi, Ross, Ross, Ryan, Ryberg, Sanger, Sawzdargo, Schweitzer, Showalter, Simiand, Sink, Sofia, Soga, Solinas, Staton, Stratford, Sugiura, Sugiura, Sugiura, Südhof, Takeda, Thomas, Thornton-Jones, Tramer, Tsou, Turu, Van Gaal, Van Sickle, Vandevoorde, Walsh, Wang, Werner, Whalley, Wiley, Wilkinson, Williams, Williams, Williams, Williams, Williamson, Wilson, Woolridge, Yamauchi, Yan, Yates, Yoshida, Zhu   +215 more
core   +3 more sources

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease [PDF]

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
*EQUAL CONTRIBUTION, Adele Romano*, Angelo Michele Lavecchia, Caterina Grillo, F.m. Laferla, Fabio Altieri, Gaurav Bedse*, Gianluigi Vendemiale, Lorenzo Federico Pace, M.r. Elphick, Silvana Gaetani, Silvia Cianci, Tommaso Cassano   +12 more
core   +1 more source

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s) [PDF]

, 2015
ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S.
Cascio, Maria G., Denovan-Wright, Eileen M., Janero, David R., Korde, Anisha, Kulkarni, Abhijit R., Kulkarni, Pushkar M., Laprairie, Robert B., Makriyannis, Alexandros, Pertwee, Roger G., Thakur, Ganesh A., Tichkule, Ritesh B., Zhou, Han, Zvonok, Nikolai   +12 more
core   +3 more sources