Results 141 to 150 of about 2,668,334 (282)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Cannabinoid receptor 2 affect the inflammatory response in periodontitis by regulating macrophage M1/M2 polarization. [PDF]

BMC Oral Health
Yuan SY, Zhao F, Tao R, Liu B, Liu CY.
europepmc   +1 more source

Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal.

Biological Psychiatry, 2015
Liting Deng, J. Guindon, Benjamin L. Cornett, A. Makriyannis, K. Mackie, A. Hohmann   +5 more
semanticscholar   +1 more source

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

Type-1 Cannabinoid Receptor Promiscuous Coupling: Computational Insights into Receptor-G Protein Interaction Dynamics. [PDF]

Int J Mol Sci
Berghella A, Stepniewski TM, Sabatucci A, Lopez-Balastegui M, Nowicki K, Dufrusine B, Selent J, Dainese E.   +7 more
europepmc   +1 more source

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Fetal calf serum (FCS) is a key supplement in cell culture, providing nutrients, and growth factors that support cancer cell proliferation. Studies suggest that compound cytotoxicity profiles in vitro vary depending on FCS concentration in culture medium. The study aimed to examine how extracellular conditions influence the in vitro
Sanele Priscillia Mathibela, Maphuti Tebogo Lebelo, Vanessa Steenkamp   +2 more
wiley   +1 more source

Cannabichromene variation in hemp cultivars

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Cannabichromene (CBC) is a nonpsychoactive cannabinoid with pharmaceutical potential that is attracting significant interest for its potential therapeutic applications. However, the factors governing CBC production in Cannabis sativa remain largely unknown. This study aimed to investigate the variation in CBC accumulation within different Type
Anthony Torres, Caleb King, Christopher S. Pauli, Thomas Blank, Donald P. Land, Kymron DeCesare, Reggie Gaudino   +6 more
wiley   +1 more source

Naringin Alleviates Autistic-Like Behaviors in BTBR Mice Through Cannabinoid Receptor Type 1-Mediated Restoration of Hippocampal Neurogenesis. [PDF]

CNS Neurosci Ther
Liu Y, Xia M, Zhang X, Luo J, Liu T, Gong H, Liu J, Chen M, Wang L, Zhao J, Gong M, Luo Y, Fan X.   +12 more
europepmc   +1 more source

Identification and Structural Elucidation of a New Synthetic Cannabinoid, MDMB‐5′Br‐PINACA, in Seized Herbal Materials

Drug Testing and Analysis, Volume 18, Issue 3, Page 334-340, March 2026.
MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi, Lucas André Zeoly, Rafael Lanaro, Ingrid Simões Oliveira, Mariana Cepollaro Diana, Mauricio Yonamine, Jose Luiz Costa   +6 more
wiley   +1 more source

Crystal structures of agonist-bound human cannabinoid receptor CB₁. [PDF]

Nature
Hua T, Vemuri K, Nikas SP, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.   +18 more
europepmc   +1 more source