Results 11 to 20 of about 74,377 (332)

Maternal sevoflurane exposure induces neurotoxicity in offspring rats via the CB1R/CDK5/p-tau pathway

Frontiers in Pharmacology, 2023
Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring.
Yuxiao Wan, Ziyi Wu, Xingyue Li, Ping Zhao   +3 more
doaj   +1 more source

Semiquantitative activity-based detection of JWH-018, a synthetic cannabinoid receptor agonist, in oral fluid after vaping [PDF]

, 2020
The rapid proliferation of new synthetic cannabinoid receptor agonists (SCRAs) has initiated considerable interest in the development of so-called “untargeted” screening strategies.
Cannaert, Annelies, Fernandez, Maria del Mar Ramirez, Ramaekers, Johannes G., Stove, Christophe, Theunissen, Eef L., Wille, Sarah   +5 more
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Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes

Pharmacology Research & Perspectives, 2022
Sexual dimorphisms are observed in cannabinoid pharmacology. It is widely reported that female animals are more sensitive to the cataleptic, hypothermic, antinociceptive, and anti‐locomotive effects of cannabinoid receptor agonists such as CP55,940 ...
Hye Ji J. Kim, Ayat Zagzoog, Tallan Black, Sarah L. Baccetto, Udoka C. Ezeaka, Robert B. Laprairie   +5 more
doaj   +1 more source

In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors

Frontiers in Neuroscience, 2021
The endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep, appetite, pain processing, and emotional behaviors related to reward.
Hye Ji J. Kim, Ayat Zagzoog, Anna Maria Smolyakova, Udoka C. Ezeaka, Michael J. Benko, Teagan Holt, Robert B. Laprairie, Robert B. Laprairie   +7 more
doaj   +1 more source

Novel putative ligands of cannabinoid receptors: synthesis and effects on cell signaling and neuronal functions [PDF]

The Ukrainian Biochemical Journal, 2023
Cannabinoid ligands are known to possess neuroprotective actions and may have utility in the treatment of neurodegeneration. The major targets for cannabinoids include the classical CB1 cannabinoid receptor, as well as the novel cannabinoid receptor ...
J. Senkiv, A. Kryshchyshyn-Dylevych, D. Khylyuk, M. Wujec, R. Stoika, A. J. Irving, R. Lesyk   +6 more
doaj   +1 more source

Endocannabinoid-related compounds in gastrointestinal diseases [PDF]

, 2018
The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro, Esposito, Giuseppe, Gigli, Stefano, Giovanni, Sarnelli, Marcella, Pesce, Osvaldo, Borrelli, Rosario, Cuomo, Seguella, Luisa   +7 more
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Influence of cannabinoid receptor GPR55 upon salivation of rat submandibular salivary gland

Біологічні студії, 2013
This paper is devoted to elucidation of functionally active cannabinoid receptor GPR55 in submandibular salivary gland cells of rats by introducing a specific agonist lysophosphatidylinositol.
S. Y. Korchynska, R. E. Makarovska, N. V. Fedirko   +2 more
doaj   +1 more source

The Vertical and Horizontal Pathways in the Monkey Retina Are Modulated by Typical and Atypical Cannabinoid Receptors

Cells, 2021
The endocannabinoid (eCB) system has been found in all visual parts of the central ner-vous system and plays a role in the processing of visual information in many species, including monkeys and humans. Using anatomical methods, cannabinoid receptors are
Joseph Bouskila, Maxime Bleau, Catarina Micaelo-Fernandes, Jean-François Bouchard, Maurice Ptito   +4 more
doaj   +1 more source

Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]

, 2012
This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J., Kreutter, M., LaCourt, M., Mantsch, John R., Stroh, G., Vaughn, Linda K., Vranjkovic, Oliver   +6 more
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Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
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