Results 281 to 290 of about 74,377 (332)
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Cannabinoids, cannabinoid receptors and tinnitus
Hearing Research, 2016One hypothesis suggests that tinnitus is a form of sensory epilepsy, arising partly from neuronal hyperactivity in auditory regions of the brain such as the cochlear nucleus and inferior colliculus. Although there is currently no effective drug treatment for tinnitus, anti-epileptic drugs are used in some cases as a potential treatment option. There is
Paul F, Smith, Yiwen, Zheng
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Progress in Neurobiology, 1996
Cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-THC). Rapid progress has been achieved in marijuana research in the last five years than in the thousands of years that marijuana has been used in human history. For many decades therefore, research on
E S, Onaivi +2 more
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Cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-THC). Rapid progress has been achieved in marijuana research in the last five years than in the thousands of years that marijuana has been used in human history. For many decades therefore, research on
E S, Onaivi +2 more
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Prostaglandins & Other Lipid Mediators, 2002
Cannabinoid receptors were named because they have affinity for the agonist delta9-tetrahydrocannabinol (delta9-THC), a ligand found in organic extracts from Cannabis sativa. The two types of cannabinoid receptors, CB1 and CB2. are G protein coupled receptors that are coupled through the Gi/o family of proteins to signal transduction mechanisms that ...
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Cannabinoid receptors were named because they have affinity for the agonist delta9-tetrahydrocannabinol (delta9-THC), a ligand found in organic extracts from Cannabis sativa. The two types of cannabinoid receptors, CB1 and CB2. are G protein coupled receptors that are coupled through the Gi/o family of proteins to signal transduction mechanisms that ...
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CB1 Cannabinoid Receptor Ligands
Mini-Reviews in Medicinal Chemistry, 2005The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications.
Ganesh A, Thakur +2 more
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Cannabinoid receptors and immunity
Immunology Today, 1998Abstract Marijuana cannabinoids are both psychoactive and immunoactive. Here, we will review evidence that cannabinoids modulate immunity and that cannabinoid receptors and endogenous ligands are expressed in immune tissues. Clues will also be presented concerning the role of the cannabinoid system in immune regulation and the possible molecular ...
T W, Klein, C, Newton, H, Friedman
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Characterization of Cannabinoid Receptors
Current Protocols in Pharmacology, 2002AbstractThis unit describes the use of cannabinoid radioligands in competitive binding assays for determining affinity parameters (IC50,Ki) of unlabeled compounds at transfected CB1 and CB2 receptors expressed in cell lines.Curr. Protoc. Pharmacol. 63:1.26.1‐1.26.10. © 2013 by John Wiley & Sons, Inc.
Richard F, Cox, Vincent, Rash
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Cannabinoid Receptor Signaling
2005The cannabinoid receptor family currently includes two types: CB1, characterized in neuronal cells and brain, and CB2, characterized in immune cells and tissues. CB1 and CB2 receptors are members of the superfamily of seven-transmembrane-spanning (7-TM) receptors, having a protein structure defined by an array of seven membrane-spanning helices with ...
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Cannabis and cannabinoid receptors
Fitoterapia, 2000Cannabis and cannabinoids exert many of their biological functions through receptor-mediated mechanisms. Two types of cannabinoid receptors have been identified, namely CB(1) and CB(2), both coupled to a G protein. CB(1) receptors have been detected in the central nervous system (where they are responsible for the characteristic effects of Cannabis ...
E. Nocerino +2 more
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Cannabinoid receptors in atherosclerosis
Current Opinion in Lipidology, 2006Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed.Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, produce their biological effects by interacting with specific receptors.
Sabine, Steffens, Francois, Mach
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Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes
Chemistry and Physics of Lipids, 2002Delta(9)-Tetrahydrocannabinol (delta(9)-THC), the primary psychoactive constituent of marijuana (Cannabis sativa), is known to bind to two cannabinoid receptors: CB(1) receptors, located primarily in the brain, and CB(2) receptors, located primarily in the periphery.
Jenny L, Wiley, Billy R, Martin
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