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Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists
Biochemical Pharmacology, 2019Cannabinoid receptors type 1 (CB1) and type 2 (CB2) are promising targets for a number of diseases, including obesity, neuropathic pain, and multiple sclerosis, among others. Upon ligand-mediated activation of these receptors, multiple receptor conformations could be stabilized, resulting in a complex pattern of possible intracellular effects. Although
Elise Wouters +3 more
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Canonical Cannabinoid Receptors
This chapter will review the basic pharmacology of the canonical cannabinoid receptors. The endocannabinoid system is a complex signalling network involved in a wide range of physiological processes, including pain modulation, appetite regulation, and synaptic plasticity.Beth, Ehrlich +3 more
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Pharmacology of Cannabinoid Receptors
Annual Review of Pharmacology and Toxicology, 1995Two subtypes of cannabinoid receptors, CB1 and CB2, have been described to date, although future investigations may elucidate other receptors. The actions of cannabimimetic agents via CB1 receptors in brain are mediated by GI/O to inhibit adenylate cyclase and Ca2+ channels. Little is known about signal transduction mechanisms utilized by CB2 receptors.
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Cannabinoid receptors and pain
Progress in Neurobiology, 2001Mammalian tissues contain at least two types of cannabinoid receptor, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB(2) receptors occur centrally and peripherally in certain non-neuronal tissues, particularly in immune cells.
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C&EN Global Enterprise, 2016
Two research groups have independently elucidated the first crystal structures of the cannabinoid receptor CB1, a cell-membrane protein involved in a host of appetite, pain-sensation, memory, and o...
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Two research groups have independently elucidated the first crystal structures of the cannabinoid receptor CB1, a cell-membrane protein involved in a host of appetite, pain-sensation, memory, and o...
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Current treatment and recent progress in gastric cancer
Ca-A Cancer Journal for Clinicians, 2021Smita S Joshi, Brian D Badgwell
exaly