Results 31 to 40 of about 2,668,334 (282)

Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target

Frontiers in Neuroscience, 2017
As a consequence of an increasingly aging population, the number of people affected by neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, is rapidly increasing.
T. Cassano, Silvio Calcagnini, L. Pace, F. De Marco, A. Romano, S. Gaetani   +5 more
semanticscholar   +1 more source

Mechanism of the Interaction of Cannabinoid System in Central Amygdale with Opioid System [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008
Background and objectives Cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. There are also functional interactions between both cannabinoid and opioid systems. In this study we investigated the
SH Sarahroodi, A Arzi, MR Zarrindast, MJ Khodayar   +3 more
doaj   +1 more source

Actions of N-arachidonyl-glycine in a rat inflammatory pain model

Molecular Pain, 2007
Background While cannabinoid receptor agonists have analgesic activity in inflammatory pain states they produce a range of side effects. Recently, it has been demonstrated that the arachidonic acid-amino acid conjugate, N-arachidonyl-glycine (NA-glycine)
Vaughan Christopher W, Mitchell Vanessa A, Succar Rebecca   +2 more
doaj   +1 more source

Cannabinoid receptors in invertebrates [PDF]

Journal of Evolutionary Biology, 2006
Abstract Two cannabinoid receptors, CB1 and CB2, are expressed in mammals, birds, reptiles, and fish. The presence of cannabinoid receptors in invertebrates has been controversial, due to conflicting evidence. We conducted a systematic review of the literature, using expanded search parameters. Evidence presented in the literature varied
J M, McPartland, J, Agraval, D, Gleeson, K, Heasman, M, Glass   +4 more
openaire   +2 more sources

Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation

Haematologica, 2016
Sickle cell anemia is a manifestation of a single point mutation in hemoglobin, but inflammation and pain are the insignia of this disease which can start in infancy and continue throughout life.
Lucile Vincent, Derek Vang, Julia Nguyen, Barbara Benson, Jianxun Lei, Kalpna Gupta   +5 more
doaj   +1 more source

High-resolution crystal structure of the human CB1 cannabinoid receptor

Nature, 2016
The human cannabinoid G-protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-AG) and to the widely consumed plant phytocannabinoid Δ9-tetrahydrocannabinol (THC ...
Zhenhua Shao, Jie Yin, Karen M. Chapman, Magdalena G Grzemska, Lindsay D. Clark, Junmei Wang, D. Rosenbaum   +6 more
semanticscholar   +1 more source

The role of cannabinoid agonists and antagonists on folliculogenesis and evolutionary events in the mouse ovary [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Cannabinoids, derivatives of Cannabis sativa L., can activate the endocannabinoid system via two endogenous receptors, CB1 and CB2. This system is crucial in regulating folliculogenesis, fertility, and reproductive function.
Vida Mirzaie, Touba Eslaminejad, Fatemeh Sheikhbahaei, Shayan Vafaei, Fatemeh Nabipour, Mina Behzadi, Seyyed Noureddin Nematollahi-Mahani   +6 more
doaj   +1 more source

Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?

Pharmaceutics, 2021
The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine.
Leontina Elena Filipiuc, Daniela Carmen Ababei, Teodora Alexa-Stratulat, Cosmin Vasilica Pricope, Veronica Bild, Raluca Stefanescu, Gabriela Dumitrita Stanciu, Bogdan-Ionel Tamba   +7 more
doaj   +1 more source

Cannabinoid CB1 and CB2 Receptor Signaling and Bias

Cannabis and Cannabinoid Research, 2017
An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different ligands can differentially activate these pathways by stabilizing a limited range of receptor conformations, which in ...
Mikkel Søes Ibsen, M. Connor, M. Glass
semanticscholar   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source