Results 91 to 100 of about 1,296,096 (233)

The Impact of the CB₂ Cannabinoid Receptor in Inflammatory Diseases: An Update

Molecules
The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat inflammatory disorders such as rheumatism or gout.
Volatiana Rakotoarivelo, Thomas Z. Mayer, Mélissa Simard, Nicolas Flamand, Vincenzo Di Marzo   +4 more
doaj   +1 more source

Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists [PDF]

, 2011
The cannabinoid CB(2) receptor is known to modulate osteoclast function by poorly understood mechanisms. Here, we report that the natural biphenyl neolignan 4'-O-methylhonokiol (MH) is a CB(2) receptor-selective antiosteoclastogenic lead structure (K(i) <
Huefner, Antje, Antje Huefner, Anavi-Goffer, Sharon, Raduner, Stefan, Schuehly, Wolfgang, Altmann, Karl-Heinz, Jonas Kleyer, Gertsch, Jürg, Juan Manuel Viveros Paredes, Stefan Raduner, Jürg Gertsch, Paredes, Juan Manuel Viveros, Wolfgang Schuehly, Karl-Heinz Altmann, Kleyer, Jonas, Sharon Anavi-Goffer   +15 more
core   +1 more source

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin, Seenipandi Arunachalam, Loay Lubbad, Fayez T. Hammad, Ernest Adeghate, Sandeep Subramanya, Shreesh Ojha   +6 more
wiley   +1 more source

Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons. [PDF]

, 2009
Hypophysiotropic TRH-synthesizing neurons of the hypothalamic paraventricular nucleus (PVN) have a critical role in the regulation of the energy homeostasis through control of the hypothalamic-pituitary-thyroid axis.
Wittmann, Gábor, Fekete, Csaba, Liposits, Zsolt, Watanabe, Masahiko, Deli, Levente, Lechan, Ronald M., Kalló, Imre   +6 more
core   +1 more source

Receptors and Channels Targeted by Synthetic Cannabinoid Receptor Agonists and Antagonists [PDF]

Current Medicinal Chemistry, 2010
It is widely accepted that non-endogenous compounds that target CB(1) and/or CB(2) receptors possess therapeutic potential for the clinical management of an ever growing number of disorders. Just a few of these disorders are already treated with Delta(9)-tetrahydrocannabinol or nabilone, both CB(1)/CB(2) receptor agonists, and there is now considerable
openaire   +2 more sources

(+)‐Trans‐Cannabidiol Is an Agonist at Human CB2 Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT (−)‐trans‐Cannabidiol ((−)‐CBD) is a principal phytocannabinoid from Cannabis sativa. (−)‐CBD has complex pharmacology but is a relatively weak inhibitor of CB1 and CB2 receptor signaling. Cannabidiol has two chiral centres and thus four stereoisomers.
Pedro Bans Burtchaell, Marina Junqueira Santiago, Chenxi Wang, Mehdi Hagdoost, Evie J. M. Clay, Dani Mohnot, Mark Connor   +6 more
wiley   +1 more source

Involvement of spinal cannabinoid receptors in the antipruritic effects of WIN 55,212-2, a cannabinoid receptor agonist

Clinical and Experimental Dermatology, 2018
Cannabinoids have been used for their analgesic and euphoric effects for millennia, but recently the antipruritic effects of cannabis have been discovered. Considering the similarities between pain and itch sensations, we hypothesized that cannabinoid receptors may play a role in the antipruritic effects of cannabinoids.To analyse the role of the ...
Bilir, K. A., Anli, G., Ozkan, E., Gunduz, O., Ulugol, A.   +4 more
openaire   +4 more sources

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Emerging strategies for exploiting cannabinoid receptor agonists as medicines [PDF]

British Journal of Pharmacology, 2009
Mandarin translation of abstractMedicines that activate cannabinoid CB1and CB2receptor are already in the clinic. These are Cesamet®(nabilone), Marinol®(dronabinol; Δ9‐tetrahydrocannabinol) and Sativex®(Δ9‐tetrahydrocannabinol with cannabidiol). The first two of these medicines can be prescribed to reduce chemotherapy‐induced nausea and vomiting ...
openaire   +2 more sources

NG2‐Glia in Central Nervous System Following Injury: From Pathological Involvement to Repair Potential

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Following CNS injury, NG2‐glia display distinct functional phases. In the early stage, NG2‐glia are rapidly activated, proliferate, migrate to the lesion site and secrete CSPGs, which form a chemical and physical barrier that inhibits axonal regeneration.
Yunyun Cai, Xin Shen, Ming Li, Junjie Li, Gang Chen   +4 more
wiley   +1 more source