Results 101 to 110 of about 1,296,096 (233)

Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma

, 2009
Gene expression profiling has revealed that the gene coding for cannabinoid receptor 1 (CB1) is highly up-regulated in rhabdomyosarcoma biopsies bearing the typical chromosomal translocations PAX3/FKHR or PAX7/FKHR.
Salazar, M, Guzmán Pastor, Manuel, Prêtre, Kathya, Schäfer, Beat, Salazar Roa, María, Oesch, S, Oesch, Susanne, Walter, Dagmar, Velasco, G, Wachtel, Marco, Guzmán, M, Walter, D, Velasco Díez, Guillermo, Schäfer, B W, Wachtel, M   +14 more
core   +1 more source

Cannabinoid‐Inspired Fluorescent Boroisoquinolines for CB1 Receptor Imaging

ChemPhotoChem, Volume 10, Issue 9, September 2026.
A cannabinoid‐inspired fluorescent boroisoquinoline, a low‐micromolar partial agonist of the human CB1 receptor, enabled imaging of CB1 receptors by confocal microscopy in live cells. The intrinsic fluorescence of our probe provides a unique opportunity for CB1 imaging while keeping receptor structure and pharmacology similar to that observed with ...
Dénes Szepesi Kovács, Csilla Nierner, Bettina Szepesi Kovács, Attila Lehotzky, Edina Szűcs, András Dávid Tóth, Dóra Judit Kiss, László Hunyady, György M. Keserű, Péter Ábrányi‐Balogh   +9 more
wiley   +1 more source

Targeting cannabinoid CB2 receptors in the Central Nervous System. Medicinal chemistry approaches with focus on neurodegenerative disorders

Frontiers in Neuroscience, 2016
Endocannabinoids activate two types of specific receptors, namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB2 ...
Gema Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franco   +5 more
doaj   +1 more source

Indazole partial agonists targeting peripheral cannabinoid receptors

Bioorganic & Medicinal Chemistry
Considerable efforts have been made to produce full agonists of cannabinoid receptors (CBRs), but there has been limited reports on partial agonists and the associated structure activity relationship (SAR) studies. Partial agonists of peripheral CBRs may have unique pharmacological profiles that provide prolonged efficacy through delayed or limited ...
Amato, George, Laudermilk, Lucas, Vasukuttan, Vineetha, Gay, Elaine A., Decker, Ann M., Snyder, Rodney, Yue, Yun Lan, Runyon, Scott, Maitra, Rangan   +8 more
openaire   +2 more sources

Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women? [PDF]

, 2009
Objective: The aim of this study was to determine whether genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity, fat distribution and obesity-related metabolic disorders in Polish postmenopausal women.Design and ...
Felicja Lwow, Diana Jedrzejuk, Lukasz Laczmanski, Andrzej Milewicz, Katarzyna Dunajska, Urszula Tworowska-Bardzinska   +5 more
core  

The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Hippocampal abnormalities are frequently associated with neurodevelopmental disorders as interneurons are crucial in establishing the network connectivity of neurons. This systematic review analyzed primary literature with a focus on aberrant hippocampal interneuron migration as an etiology for neurodevelopmental disorders, summarizing the ...
M. A. C. Till, H. M. O. Reid, I. Murphy, B. R. Christie   +3 more
wiley   +1 more source

The regulation of endocannabinoids after neuronal damage and the neuroprotective impact of GPR55 in organotypic hippocampal slice cultures [PDF]

, 2013
Endocannabinoids (eCB) are signaling lipids and became known for their importance in the central nervous system as well as in immune defense. Beneficial effects of eCB are shown in processes of excitotoxic lesion, secondary damage and neuronal plasticity
Kallendrusch, Sonja
core  

Clinical effects of cannabis compared to synthetic cannabinoid receptor agonists (SCRAs): a retrospective cohort study of presentations with acute toxicity to European hospitals between 2013 and 2020. [PDF]

INTRODUCTION Cannabis is the most common recreational drug worldwide and synthetic cannabinoid receptor agonists are currently the largest group of new psychoactive substances. The aim of this study was to compare the clinical features and outcomes of
Dines, Alison M, Badaras, Robertas, Põld, Kristiina, Kutubidze, Soso, Nitescu, Gabriela Viorela, Schmid, Yasmin, Liguts, Viesturs, Chamoun, Karam, Zacharov, Sergej, Gresnigt, Femke M J, Brvar, Miran, Daveloose, Laurence, Vallersnes, Odd Martin, Bitel, Marcin, Ceschi, Alessandro, Konstari, Jutta, Noseda, Roberta, Scholz, Irene, Jürgens, Gesche, Lyphout, Cathelijne, Giraudon, Isabelle, Liechti, Matthias E, Waters, Mitchell L, Eyer, Florian, Radenkova-Saeva, Julia, Van den Hengel-Koot, Irma, Heyerdahl, Fridtjof, Vigorita, Federico, Dargan, Paul I, Mégarbane, Bruno, Perminas, Marius, Waring, William Stephen, Persett, Per Sverre, Waldman, Wojciech, Zellner, Tobias, Puchon, Erik, Grenc, Damjan, Wood, David M, Miró, Òscar, Gartner, Birgit, Bonnici, Jeffrey, Laubner, Gabija, Samer, Caroline, Moughty, Adrian, Liakoni, Evangelia, Calýskan, Feriyde, Paasma, Raido, Caganova, Blazena, Rulisek, Jan, McKenna, Roy, Hondebrink, Laura, Stašinskis, Roberts, Yates, Christopher, Gorozia, Ketevan, O'Connor, Niall, Puiguriguer, Jordi, Hovda, Knut Erik, Anseeuw, Kurt, Ortega Perez, Juan, Galicia, Miguel, Vogt, Severin, Surkus, Jonas   +61 more
core   +2 more sources

Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 5, September 2026.
ABSTRACT Objective This review critically examines psilocybin, with particular emphasis on its pharmacokinetics and pharmacodynamics, including its serotonergic, neuroplastic, and anti‐inflammatory mechanisms. It integrates historical context, preclinical and clinical evidence, and evaluates emerging therapeutic potential, safety, microdosing practices,
José Norberto Vásquez‐Bonilla
wiley   +1 more source

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source