Results 141 to 150 of about 1,296,096 (233)

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

The use and effects of synthetic cannabinoid receptor agonists by New South Wales cannabis treatment clients. [PDF]

J Cannabis Res, 2021
Jackson MA, Brown AL, Johnston J, Clancy R, McGregor I, Bruno R, Lintzeris N, Montebello M, Luksza J, Bowman J, Phung N, Allsop D, Dunlop AJ.   +12 more
europepmc   +1 more source

Phase I In Vitro Metabolic Profiling of the Synthetic Cannabinoid Receptor Agonists CUMYL-THPINACA and ADAMANTYL-THPINACA. [PDF]

Metabolites, 2021
Monti MC, Scheurer E, Mercer-Chalmers-Bender K.   +2 more
europepmc   +1 more source

In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity. [PDF]

Metabolites, 2021
Richter MJ, Wagmann L, Gampfer TM, Brandt SD, Meyer MR.   +4 more
europepmc   +1 more source

Role of type 2 cannabinoid receptor in bone metabolism [PDF]

, 2009
Cannabinoid receptors play an important role in regulating bone mass and bone turnover. Studies in our laboratories have shown that young mice lacking type 1 cannabinoid receptor (CNR1-/-) had increased bone mass and were resistant to ovariectomy ...
Sophocleous, Antonia
core  

United Nations Office on Drugs and Crime: Recommended methods for the Identification and Analysis of Synthetic Cannabinoid Receptor Agonists in Seized Materials. [PDF]

Forensic Sci Int Synerg, 2021
Tettey JNA, Crean C, Rodrigues J, Angeline Yap TW, Lee Wendy Lim J, Shirley Lee HZ, Ching M.   +6 more
europepmc   +1 more source

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market. [PDF]

Molecules, 2021
Brandon AM, Antonides LH, Riley J, Epemolu O, McKeown DA, Read KD, McKenzie C.   +6 more
europepmc   +1 more source

Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists. [PDF]

Pharmacol Res Perspect, 2020
Sachdev S, Banister SD, Santiago M, Bladen C, Kassiou M, Connor M.   +5 more
europepmc   +1 more source

Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.

, 1992
The physiologic activity of (-)-delta 9-tetrahydrocannabinol, the most active component of marijuana, and of many synthetic cannabimimetics may be mediated either through receptor binding and functional coupling to specific signal transduction pathways ...
Briley, E M, Veluz, J S, Matsuda, L A, Felder, C C, Williams, H L   +4 more
core   +1 more source

Entomological consequences and toxicological detection of synthetic cannabinoid receptor agonists (SCRAs) in necrophagous larvae (Diptera: Calliphoridae). [PDF]

Int J Legal Med
Blavier CAK, Villet MH, Zschiesche A, Auwärter V, Graw M, Geffert C, Groth OC.   +6 more
europepmc   +1 more source