Results 131 to 140 of about 1,296,096 (233)

Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11. [PDF]

Front Psychiatry, 2022
Kevin RC, Cairns EA, Boyd R, Arnold JC, Bowen MT, McGregor IS, Banister SD.   +6 more
europepmc   +1 more source

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5440-5457, September 2026.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli   +8 more
wiley   +1 more source

"Spice"-related deaths in and around Munich, Germany: A retrospective look at the role of synthetic cannabinoid receptor agonists in our post-mortem cases over a seven-year period (2014-2020). [PDF]

Int J Legal Med, 2023
Groth O, Roider G, Angerer V, Schäper J, Graw M, Musshoff F, Auwärter V.   +6 more
europepmc   +1 more source

Fentanyl Detection in Biological Samples From Individuals Reporting Synthetic Cannabinoid Use in São Paulo, Brazil

Drug and Alcohol Review, Volume 45, Issue 6, September 2026.
ABSTRACT Introduction Brazil has historically exhibited low illicit opioid prevalence, though forensic data indicate rising fentanyl seizures, often in combination with other substances. People who use Synthetic cannabinoid receptor agonists (SCRA) are particularly vulnerable to unintentional fentanyl exposure due to the unpredictable chemical ...
Ligia Goes Endo, Rodrigo Alves de Oliveira, Ivan Dieb Miziara, Mauricio Yonamine, João Maurício Castaldelli‐Maia, Vilma Leyton, Henrique Silva Bombana   +6 more
wiley   +1 more source

Quantitation of Synthetic Cannabinoid Receptor Agonists in Postmortem Blood Using a Single Point Calibration. [PDF]

Acad Forensic Pathol, 2021
Sharp P, Hudson S, Morley SR.
europepmc   +1 more source

Positioning Incretin‐Based and Next‐Generation Obesity Management Medications: A Methodological Framework for a Series of Systematic Reviews and Network Meta‐Analyses

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7768-7778, September 2026.
ABSTRACT Background The obesity pharmacotherapy landscape is evolving rapidly, with several approved incretin‐based therapies and an expanding pipeline of investigational compounds targeting multiple metabolic pathways. Conventional evidence syntheses often struggle to accommodate differences in dose selection, treatment duration and stage of clinical ...
Matteo Monami, Benedetta Ragghianti, Edoardo Mannucci   +2 more
wiley   +1 more source

Clinical withdrawal symptom profile of synthetic cannabinoid receptor agonists and comparison of effects with high potency cannabis. [PDF]

Psychopharmacology (Berl), 2022
Craft S, Ferris JA, Barratt MJ, Maier LJ, Lynskey MT, Winstock AR, Freeman TP.   +6 more
europepmc   +1 more source

Administração de canabinóides no sistema nervoso central facilita a extinção de memórias aversivas em ratos [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Recentemente, estudos têm demonstrado a capacidade do sistema endocanabinóide (eCB) em modular estados emocionais e ...
Bitencourt, Rafael Mariano de
core  

N‐Arachidonoyl‐phosphatidylethanolamide phospholipase D activation by muscarinic receptors

The Journal of Physiology, Volume 604, Issue 18, Page 7721-7738, 15 September 2026.
Abstract figure legend Activating muscarinic M3 receptors activates Gq‐pathway signalling, including the activation of phospholipase C (PLC) and release of calcium from internal stores as shown in the upper panel. It remains unclear whether the calcium acts on N‐arachidonoyl‐phosphatidylethanolamide phospholipase D (NAPE‐PLD) itself or upstream at N ...
Natalia Murataeva, Connor Schmitt, Elyssa Hyman, Jim Wager‐Miller, Irene Matthews, Ruyi Cai, Shangxuan Cai, Yulong Li, Ken Mackie, Alex Straiker   +9 more
wiley   +1 more source

Cannabinoid Receptor Agonists for the Potential Treatment of Pain, Neurological Disorders, Fibrotic Diseases, Obesity, and Many More. [PDF]

ACS Med Chem Lett, 2021
Abdel-Magid AF.
europepmc   +1 more source