Results 91 to 100 of about 247,999 (295)

Modulation of Pilocarpine-Induced Seizures by Cannabinoid Receptor 1

PLoS ONE, 2014
Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain. Endocannabinoids act at the cannabinoid CB1 receptors to reduce neurotransmitter release and the severity
Rebecca L Kow, Kelly Jiang, Alipi V Naydenov, Joshua H Le, Nephi Stella, Neil M Nathanson   +5 more
openaire   +4 more sources

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats

BMC Genetics, 2010
Background Genetic variation in the regulatory region of the human serotonin transporter gene (SLC6A4) has been shown to affect brain functionality and personality.
Nijman Isaäc J, Homberg Judith, Kuijpers Sylvia, Cuppen Edwin   +3 more
doaj   +1 more source

Intra-Testicular Signals Regulate Germ Cell Progression and Production of Qualitatively Mature Spermatozoa in Vertebrates [PDF]

, 2014
Spermatogenesis, a highly conserved process in vertebrates, is mainly under the hypothalamic-pituitary control, being regulated by the secretion of pituitary gonadotropins, FSH and LH, in response to stimulation exerted by Gonadotropin Releasing Hormone (
Gilda Cobellis, Riccardo Pierantoni, Rosanna Chianese, Rosaria Meccariello, Silvia Fasano, Teresa Chioccarelli, Vincenza Ciaramella   +6 more
core   +2 more sources

Potential of solid‐state microwaves in lab‐scale chemical‐process development

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The integration of a solid‐state microwave (MW) generator into a newly designed, versatile MW reactor ensures improved energy efficiency, precise process control and broader application potential. In its most particular feature, the device supports the modification of dielectric‐radiation orientation and can be operated under ...
Christian Cravotto, Clelia Aimone, Giorgio Capaldi, Giorgio Grillo, Giancarlo Cravotto   +4 more
wiley   +1 more source

Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans

Frontiers in Molecular Biosciences, 2018
Endocannabinoid peptides, or “pepcans,” are endogenous ligands of the CB1 cannabinoid receptor. Depending on their length, they display diverse activity: For instance, the nona-peptide Pepcan-9, also known as hemopressin, is a powerful inhibitor of CB1 ...
Alessandro Emendato, Remo Guerrini, Erika Marzola, Hans Wienk, Rolf Boelens, Serena Leone, Delia Picone   +6 more
doaj   +1 more source

Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]

, 2019
CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P., Dvorácskó, Szabolcs, MINOSI, PAOLA, MOLLICA, Adriano, PIERETTI, Stefano, Stefanucci, Azzurra, Tömböly, Csaba, Zengin, Gokhan   +7 more
core   +2 more sources

Differentiating Nonsuicidal Self‐Injury (NSSI) From Suicide Attempts in Adolescents: A Pilot Study

Medicine Bulletin, EarlyView.
ABSTRACT Background Differentiating between nonsuicidal self‐injury (NSSI) and suicide attempts (SA) in adolescents is crucial due to distinct underlying motivations, treatment needs, and potential outcomes associated with each behavior.
María Posada‐Ayala, Ping Wang, Gemma Barroso‐Garcia, Encarnación Donoso‐Navarro, Elena Hernandez‐Alvarez, María Gil‐Ligero, Julián Romero, Silvia Rosado‐Garcia, Antonio José Sánchez‐López, Hilario Blasco‐Fontecilla   +9 more
wiley   +1 more source

Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting

Pharmaceuticals, 2010
Chemotherapy-induced nausea and vomiting (CINV) is a complex pathophysiological condition and consists of two phases. The conventional CINV neurotransmitter hypothesis suggests that the immediate phase is mainly due to release of serotonin (5-HT) from ...
Nissar A. Darmani
doaj   +1 more source

The photoswitchable cannabinoid azo-HU308 enables optical control of Ca²⁺ dynamics in INS-1 β-cells via off-target effects on TRPC channels. [PDF]

FEBS Open Bio
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Viray AEG, Frank JA.
europepmc   +2 more sources