Results 91 to 100 of about 56,803 (285)

Cannabinoid Ligands Targeting TRP Channels

Frontiers in Molecular Neuroscience, 2019
Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli.
Chanté Muller, Paula Morales, Patricia H. Reggio   +2 more
doaj   +1 more source

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse [PDF]

, 2019
In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK).
Alganga, Husam, Ballantyne, Margaret D., Ewart, Marie-Ann, Fertig, Bracy, Greig, Fiona H., Kazi, Zeshan H., Kennedy, Simon, Nather, Katrin, Pyne, Nigel J., Pyne, Susan, Zaborska, Karolina E.   +10 more
core   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications

Neural Plasticity, 2016
Cannabis is one of the most prevalent drugs used in industrialized countries. The main effects of Cannabis are mediated by two major exogenous cannabinoids: ∆9-tetrahydroxycannabinol and cannabidiol.
Thomas Schwitzer, Raymund Schwan, Karine Angioi-Duprez, Anne Giersch, Vincent Laprevote   +4 more
doaj   +1 more source

The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective [PDF]

, 2019
© 2019 Orsolini, Chiappini, Papanti, De Berardis, Corkery and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania, Corkery, John Martin, De Berardis, Domenico, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +5 more
core   +2 more sources

Neurobiology of cannabinoid receptor signaling

Dialogues in Clinical Neuroscience, 2020
The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous system. Despite its widespread localization, its functions within the context of distinct neural processes are very well discernable and specific. This is remarkable, and the question remains as to how such specificity is achieved.
openaire   +3 more sources

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Aspectos terapêuticos de compostos da planta Cannabis sativa

Química Nova, 2006
Several cannabinoid compounds present therapeutic properties, but also have psychotropic effects, limiting their use as medicine. Nowadays, many important discoveries on the compounds extracted from the plant Cannabis sativa (cannabinoids) have ...
Honório Káthia Maria, Arroio Agnaldo, Silva Albérico Borges Ferreira da   +2 more
doaj  

Cannabinoids and alcohol co-exposure modulate pathogen-induced pulmonary immune responses

Frontiers in Immunology
Both alcohol and cannabinoid misuse cause substantial societal problems individually, and cannabis is the most popular illicit drug used simultaneously with alcohol.
De’Jana Parker, Vijay Sivaraman
doaj   +1 more source

Cannabinoids and Pain

Pain Research and Management, 2001
Cannabinoids have been used to treat pain for many centuries. However, only during the past several decades have rigorous scientific methods been applied to understand the mechanisms of cannabinoid action.
J Michael Walker, Nicole M Strangman, Susan M Huang   +2 more
doaj   +1 more source