Results 71 to 80 of about 56,803 (285)

Activity-based detection of consumption of synthetic cannabinoids in authentic urine samples using a stable cannabinoid reporter system [PDF]

, 2017
Synthetic cannabinoids (SCs) continue to be the largest group of new psychoactive substances (NPS) monitored by the European Monitoring Center of Drugs and Drugs of Abuse (EMCDDA).
Auwärter, Volker, Cannaert, Annelies, Franz, Florian, Stove, Christophe   +3 more
core   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Cannabis; epidemiological, neurobiological and psychopathological issues: an update [PDF]

, 2017
This document is the Accepted Manuscript version of the following article: Maria Antonietta De Luca, Gaetano Di Chiara, Cristina Cadoni, Daniele Lecca, Laura Orsolini, Duccio Papanti, John Corkery, Fabrizio Schifano, 'Cannabis; Epidemiological ...
Cadoni, Cristina, Corkery, John, De Luca, Maria Antonietta, Di Chiara, Gaetano, Lecca, Daniele, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +7 more
core   +3 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Cannabinoid CB1 receptors regulate salivation

Scientific Reports, 2022
Saliva serves multiple important functions within the body that we typically take for granted, such as helping prepare food for swallowing and defense against oral pathogens.
Kelsey Andreis, Jenna Billingsley, Kian Naimi Shirazi, Jim Wager-Miller, Clare Johnson, Heather Bradshaw, Alex Straiker   +6 more
doaj   +1 more source

New Insights into Cannabis Consumption; Abuses and Possible Therapeutic Effects [PDF]

, 2015
Cannabis is one of the oldest psychotropic drugs known to humanity. The paper assesses the current knowledge on the cannabis, including the mechanisms of action and the therapeutic potential of cannabinoids.
Baconi, Daniela Luiza, Bălălău, Cristian, Vasile, Robert Daniel   +2 more
core   +3 more sources

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

Bulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon, Jiyeong Hong, Hanbin Oh, Chi Hwan Lee, Ki Hun Kim   +4 more
wiley   +1 more source

CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]

, 2015
Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A., Doncheck, Elizabeth M., Ganzman, Geoffrey S., Hillard, Cecilia J., Mantsch, John R., McReynolds, Jayme R., Vranjkovic, Oliver   +6 more
core   +2 more sources

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Bisogno, Chiang, Cravatt, Cravatt, De Marchi, Despres, Devane, Di, Di Marzo, Di Marzo, Fernandez, Freund, Giuffrida, Giuffrida, Habayeb, Klein, Klein, Maccarrone, Matsuda, Munro, Obata, Parolaro, Pertwee, Randall, Sipe, Sparling, Sugiura, Wagner, Wagner, Walker, Yamaji   +30 more
core   +1 more source