Results 151 to 160 of about 28,905 (252)

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Cannabinoid Receptors CB1 and CB2 Activation Restores Hippocampal Lipid Profiles and Alleviates Autism-Like Behaviors in Valproic Acid-Induced ASD Rats. [PDF]

CNS Neurosci Ther
Wang H, Zhang M, Yang S, Jiang Y, Wu L, Sun C.   +5 more
europepmc   +1 more source

Canine immune cells express high levels of CB₁ and CB₂ cannabinoid receptors and cannabinoid-mediated alteration of canine cytokine production is vehicle-dependent. [PDF]

Vet Immunol Immunopathol, 2023
Brown C, Mitsch M, Blankenship K, Campbell C, Pelanne M, Sears J, Bell A, Olivier AK, Ross MK, Archer T, Kaplan BLF.   +10 more
europepmc   +1 more source

Acute Encephalopathy in a Patient With Chronic Isotretinoin Exposure and Frequent Rizatriptan Use: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Acute encephalopathy in patients with prolonged isotretinoin exposure should prompt careful assessment of undisclosed or non‐prescribed medication use. This case suggests a possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and acute encephalopathy, but does not establish a definitive drug–drug ...
Soheil Roshanzamiri, Mitra Rahimi, Shahin Shadnia, Peyman Erfantalab Evini, Faraz Zandiyeh, Babak Mostafazadeh   +5 more
wiley   +1 more source

Prenatal Downregulation of CB₁ Cannabinoid Receptors in the Mouse Prefrontal Cortex Disrupts Cortical Lamination and Induces a Transcriptional Signature Associated with Social Interaction Deficits. [PDF]

J Neurosci
Simón-Sánchez S, den Boon F, García-Rincón D, Skrempou G, Paraíso-Luna J, Aguilera A, Nieto M, Werkman TR, Guzmán M, Chameau P, Galve-Roperh I.   +10 more
europepmc   +1 more source

The cannabinoid receptors system in horses: Tissue distribution and cellular identification in skin. [PDF]

J Vet Intern Med, 2022
Kupczyk P, Rykala M, Serek P, Pawlak A, Slowikowski B, Holysz M, Chodaczek G, Madej JP, Ziolkowski P, Niedzwiedz A.   +9 more
europepmc   +1 more source

Regional Functional Molecular Profiles Within the Mammalian Cortex: A Commentary on Limbic Mesocortex

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
Two lateral mouse brain sagittal sections labeled, respectively, for Lypd1 (A) and Kcnab3 (B). (A) Lypd1 labels positively cortical Layers 2 and 5 (less heavily), but only at limbic mesocortical sites, forming the limbic ring that separates the unlabeled isocortex (IsoCx) from the unlabeled hippocampal and olfactory allocortex (Hi, Sub, ERh; OlfCx ...
Luis Puelles, Elena Garcia‐Calero
wiley   +1 more source

Cannabinoid Receptors Reduced Early Brain Damage by Regulating NOX-2 and the NLRP3 Inflammasome in an Animal Model of Intracerebral Hemorrhage. [PDF]

CNS Neurosci Ther
Martínez-Torres AM, Ramírez-Celis C, Morán J.   +2 more
europepmc   +1 more source

Activation of Peripheral Cannabinoid Receptors Synergizes the Effect of Systemic Ibuprofen in a Pain Model in Rat. [PDF]

Pharmaceuticals (Basel), 2022
Díaz-Reval MI, Cárdenas Y, Huerta M, Trujillo X, Sánchez-Pastor EA, González-Trujano ME, Virgen-Ortíz A, Pérez-Hernández MG.   +7 more
europepmc   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, Volume 18, Issue 8, Page 1097-1113, August 2026.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source