Results 211 to 220 of about 56,803 (285)

Addiction‐related problems in Japan: A regional perspective

open access: yesAddiction, Volume 121, Issue 5, Page 1316-1324, May 2026.
Abstract Japan's addiction landscape appears paradoxical. The lifetime use of illicit drugs is among the lowest in Organisation for Economic Cooperation and Development countries, but harm from alcohol, tobacco, and gambling ranks among the world's highest.
Soichiro Ide   +19 more
wiley   +1 more source

The art of tolerance [PDF]

open access: yes, 1998
M Terakura   +12 more
core   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska   +2 more
wiley   +1 more source

Higher THC Concentration Medicinal Cannabis Products Efficacy and Safety Considerations: A Rapid Review

open access: yesDrug and Alcohol Review, Volume 45, Issue 4, May 2026.
ABSTRACT Issues Higher delta‐9‐tetrahydrocannabinol (THC) concentration medicinal cannabis products are characterised by a higher THC and minimal cannabidiol (CBD) content. This rapid review aims to systematically summarise and evaluate the available evidence regarding the efficacy and safety of higher THC potency medicinal cannabis products relevant ...
Myfanwy Graham   +3 more
wiley   +1 more source

Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation. [PDF]

open access: yesSci Rep
Zeng F   +9 more
europepmc   +1 more source

Exploring Age and Sex Differences in the Use of Cannabis Vaping Products: Results From the Canadian Cannabis Survey 2020–2023

open access: yesDrug and Alcohol Review, Volume 45, Issue 4, May 2026.
ABSTRACT Introduction Use of cannabis vaping products has been increasing in Canada. This study examined the prevalence and patterns of use of cannabis vaping products, including higher‐risk use, by sex and age. Methods Data were from four cycles of the Canadian Cannabis Survey, an annual web‐based survey of people aged ≥ 16 years in Canada.
Fathima Fataar   +3 more
wiley   +1 more source

Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”

open access: yesEuropean Journal of Neuroscience, Volume 63, Issue 9, May 2026.
The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon   +4 more
wiley   +1 more source

Effect of a Single Oral Dose of Dexamphetamine or Zolpidem on Attention and Reaction Time in Healthy Men

open access: yesFundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Psychotropic medicines are known to impair cognitive function acutely, but the specific effects of individual substances remain underexplored. This study investigates the effects of dexamphetamine and zolpidem on cognitive performance to quantify the potential risk of intake and their pharmacokinetic and pharmacodynamic relationship.
Veronika Pfoser‐Poschacher   +6 more
wiley   +1 more source

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