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Cannabis and cannabinoid receptors
Fitoterapia, 2000Cannabis and cannabinoids exert many of their biological functions through receptor-mediated mechanisms. Two types of cannabinoid receptors have been identified, namely CB(1) and CB(2), both coupled to a G protein. CB(1) receptors have been detected in the central nervous system (where they are responsible for the characteristic effects of Cannabis ...
E. Nocerino +2 more
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Cannabinoid receptors and their ligands
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002There are at least two types of cannabinoid receptors, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors exist primarily on central and peripheral neurons, one of their functions being to modulate neurotransmitter release. CB(2) receptors are present mainly on immune cells.
R G, Pertwee, R A, Ross
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Characterization of Cannabinoid Receptors
Current Protocols in Pharmacology, 2002AbstractThis unit describes the use of cannabinoid radioligands in competitive binding assays for determining affinity parameters (IC50,Ki) of unlabeled compounds at transfected CB1 and CB2 receptors expressed in cell lines.Curr. Protoc. Pharmacol. 63:1.26.1‐1.26.10. © 2013 by John Wiley & Sons, Inc.
Richard F, Cox, Vincent, Rash
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Pharmacology of Cannabinoid Receptors
Annual Review of Pharmacology and Toxicology, 1995Two subtypes of cannabinoid receptors, CB1 and CB2, have been described to date, although future investigations may elucidate other receptors. The actions of cannabimimetic agents via CB1 receptors in brain are mediated by GI/O to inhibit adenylate cyclase and Ca2+ channels. Little is known about signal transduction mechanisms utilized by CB2 receptors.
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Progress in Neurobiology, 1996
Cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-THC). Rapid progress has been achieved in marijuana research in the last five years than in the thousands of years that marijuana has been used in human history. For many decades therefore, research on
E S, Onaivi +2 more
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Cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-THC). Rapid progress has been achieved in marijuana research in the last five years than in the thousands of years that marijuana has been used in human history. For many decades therefore, research on
E S, Onaivi +2 more
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Cannabinoid Receptors and Their Role in Neuroprotection
NeuroMolecular Medicine, 2005Two G protein-coupled receptors for marijuana's psychoactive component, Delta9-tetrahydrocannabinol, have been cloned to date, the cannabinoid CB1 and CB2 receptors. These two proteins, the endogenous lipids that activate them, also known as endocannabinoids, and the proteins for the biosynthesis and inactivation of these ligands constitute the ...
M van der Stelt, V Di Marzo
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Cannabinoid receptors and pain
Progress in Neurobiology, 2001Mammalian tissues contain at least two types of cannabinoid receptor, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB(2) receptors occur centrally and peripherally in certain non-neuronal tissues, particularly in immune cells.
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Canonical Cannabinoid Receptors
This chapter will review the basic pharmacology of the canonical cannabinoid receptors. The endocannabinoid system is a complex signalling network involved in a wide range of physiological processes, including pain modulation, appetite regulation, and synaptic plasticity.Beth, Ehrlich +3 more
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Cannabinoid Receptor Signaling
2005The cannabinoid receptor family currently includes two types: CB1, characterized in neuronal cells and brain, and CB2, characterized in immune cells and tissues. CB1 and CB2 receptors are members of the superfamily of seven-transmembrane-spanning (7-TM) receptors, having a protein structure defined by an array of seven membrane-spanning helices with ...
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Evidence for a Cannabinoid Receptor in Immunomodulation by Cannabinoid Compounds
1993A number of structurally related cannabinoid compounds, including the major psychoactive component of marihuana, delta-9-tetrahydrocannabinol (Δ9-THC), have been widely established as being immunosuppressive. Although much has been learned with respect to which immune responses demonstrate sensitivity to modulation by cannabinoids, the mechanism(s ...
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