Results 81 to 90 of about 56,314 (199)
Aspectos terapêuticos de compostos da planta Cannabis sativa
Química Nova, 2006 Several cannabinoid compounds present therapeutic properties, but also have psychotropic effects, limiting their use as medicine. Nowadays, many important discoveries on the compounds extracted from the plant Cannabis sativa (cannabinoids) have ...
Honório Káthia Maria +2 more
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Cannabinoids and alcohol co-exposure modulate pathogen-induced pulmonary immune responses
Frontiers in ImmunologyBoth alcohol and cannabinoid misuse cause substantial societal problems individually, and cannabis is the most popular illicit drug used simultaneously with alcohol.
De’Jana Parker, Vijay Sivaraman
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Pain Research and Management, 2001 Cannabinoids have been used to treat pain for many centuries. However, only during the past several decades have rigorous scientific methods been applied to understand the mechanisms of cannabinoid action.
J Michael Walker +2 more
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Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]
, 2016 Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor +18 more
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Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
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Expression of cannabinoid receptors in human osteoarthritic cartilage: implications for future therapies [PDF]
, 2016 Introduction: Cannabinoids have shown to reduce joint damage in animal models of arthritis and reduce matrix metalloproteinase expression in primary human steoarthritic (OA) chondrocytes. The actions of cannabinoids are mediated by a number of receptors,
Bunning, Rowena A.D. +4 more
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Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection
Pharmacological ResearchΔ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova +2 more
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Computer modeling of Cannabinoid receptor type 1
ITM Web of Conferences, 2018 Cannabinoid receptors are important class of receptors as they are involved in various physiological processes such as appetite, pain-sensation, mood, and memory.
Sapundzhi Fatima +3 more
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Journal of Pharmacological Sciences, 2004 Cannabis consumption may induce psychotic states in normal individuals, worsen psychotic symptoms of schizophrenic patients, and may facilitate precipitation of schizophrenia in vulnerable individuals.
Hiroshi Ujike, Yukitaka Morita
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Biochemistry of the Endogenous Ligands of Cannabinoid Receptors
Neurobiology of Disease, 1998 In 1992 the discovery of the first endogenous ligand of cannabinoid receptors, anandamide, provided conclusive support to the hypothesis that an “endogenous cannabinoid regulatory system” exists in mammalian nervous tissue.
Vincenzo Di Marzo, Dale G. Deutsch
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