Physiological effect and pharmacokinetic evaluation of combined oral administration of cannabidiolic acid and cannabigerolic acid in dogs. [PDF]
Koll MM +4 more
europepmc +1 more source
Macrophage: Biological Functions, Diseases, and Therapeutic Targets
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun +4 more
wiley +1 more source
Impact of CBD and hemp oil use on drug test results: a systematic review. [PDF]
Ovat DY +4 more
europepmc +1 more source
1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa +17 more
wiley +1 more source
Editorial: The role of cannabinoids and the endocannabinoid system in anti-cancer therapy. [PDF]
Franks LN, Raup-Konsavage W, Fonseca BM.
europepmc +1 more source
Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley +1 more source
Mitochondrial dysfunction and autophagy activation underlie NK cell impairment induced by Cannabis. [PDF]
Bolduc AA +4 more
europepmc +1 more source
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis
Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu +7 more
wiley +1 more source
Analysis of Novel Cannabis Products Labeled as Containing THC-JD. [PDF]
Munger KR +3 more
europepmc +1 more source
The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma
CB1 and CB2 receptors are widely distributed in both normal and cancerous cells. Cannabinoids have a positive impact on reducing tumor growth in mice. A positive relationship exists between CB2 receptors and survival in skin melanoma. However, there is a negative impact on non‐small cell lung cancer and colon cancer, whereas a higher association of CB1
Farideh A. Javid +3 more
wiley +1 more source

