Results 201 to 210 of about 28,895 (261)

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies. [PDF]

Cancer Rep (Hoboken)
Mathibela SP, Lebelo MT, Steenkamp V.
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Cannabinoids for Dermatological Applications: Mechanistic Insights, Clinical Evidence, and Emerging Nanotechnology-Enabled Delivery Strategies. [PDF]

Pharmaceutics
Pareek A, Kumari L, McMahon LR, Chuturgoon A, Pareek A.   +4 more
europepmc   +1 more source

Delta‐9‐Tetrahydrocannabinol (THC) Before Bedtime: Feasibility and Mechanistic Pilot Study on Sleep and Cardiac Autonomic Activity

Journal of Sleep Research, Volume 35, Issue 4, August 2026.
ABSTRACT Disordered sleep is a common reason individuals report using cannabis, yet the physiological effects of Δ9‐tetrahydrocannabinol (Δ9‐THC) on sleep and autonomic regulation remain incompletely understood. Early studies reported acute sleep‐promoting effects of Δ9‐THC, but chronic use has been associated with disrupted sleep and possible ...
Joshua E. Gonzalez, Alicia V. Stewart, Jacquelin L. Ellison, Omar H. Ordaz, LaTroy D. Robinson, Noal A. Clemons, Jonathan S. Emens, Sean P. M. Rice, Steven A. Shea, Nicole P. Bowles   +9 more
wiley   +1 more source

Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review. [PDF]

J Cannabis Res
Castro SG, Silva SE, Brito JCM, Matavel A.   +3 more
europepmc   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

Therapeutic potential of acidic cannabinoids: an update. [PDF]

J Cannabis Res
Singh SK, Antoine C, Tse C, Ji L, Reed M, Carter WG, Trezza V, Bid HK.   +7 more
europepmc   +1 more source

Alcohol and Cannabinoids Differentially Regulate Macrophage Polarization, with Co-Exposure Producing an Antagonistic Immunomodulatory Effect. [PDF]

Int J Mol Sci
Shake EP, Vargas Santos G, Sivaraman V.
europepmc   +1 more source

Comprehensive Profiling of Phytocannabinoids and Semisynthetic Cannabinoids in Seized Materials from Northern Italy. [PDF]

ACS Omega
Casati S, Bergamaschi RF, Sicuro L, Ravelli A, Vanerio S, Orsi V, Ronco C, Torretta E, Rimoldi A, Roda G, Battistini A, Mollica L, Mollica L, Rota P.   +13 more
europepmc   +1 more source