Results 231 to 240 of about 50,545 (304)

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Fenebrutinib and Effect on the QT/QTc Interval in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Fenebrutinib is a Bruton's tyrosine kinase inhibitor under investigation for the treatment of multiple sclerosis. The goal of this study was to investigate the effect of fenebrutinib on cardiac repolarization (QT interval) as well as its safety, tolerability, and pharmacokinetics in healthy participants.
Yan Xu, Sonoko Kawakatsu, Denison Kuruvilla, John N. Ratchford, Qi Qi, Malgorzata Sierzega, Lin Pan, Jiajie Yu   +7 more
wiley   +1 more source

‘SASADECC’—A Unique Model of Collaborative Care Between Government and Non‐Government Health Services for Adolescents With Complex Substance Use Issues

Drug and Alcohol Review, Volume 45, Issue 3, March 2026.
ABSTRACT Introduction Despite the importance of early intervention, major treatment gaps exist for adolescents with substance use issues. This report describes a unique collaboration between government and non‐government health services—The Specialist Addiction Service for Adolescents (SASA) adolescent addiction psychiatry service and Sydney Drug ...
David E. A. Gordon, Belinda Volkov, Arezu Akbarian, Lauren A. Monds, Mark Montebello   +4 more
wiley   +1 more source

Exploring the neuroprotective effects of phytocannabinoids on oxygen-glucose deprived neurons in an in vitro model of stroke. [PDF]

J Cannabis Res
Chatragadda B, Potts EM, Collins A, Ma H, Fallini C.   +4 more
europepmc   +1 more source

Study participant impression of use and satisfaction with STS101 (dihydroergotamine nasal powder): Results from the open‐label ASCEND acute migraine study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 688-696, March 2026.
Abstract Objective/Background This study was undertaken to assess participants' impression of use and satisfaction with STS101 in a long‐term, open‐label safety study. The ASCEND study assessed the safety and tolerability of STS101, an investigational drug–device combination of 5.2 mg dihydroergotamine in a single‐use nasal delivery device for the ...
Jessica Ailani, Larry Charleston IV, Shannon Strom, Detlef Albrecht, Robert Cowan   +4 more
wiley   +1 more source

Genotype and chemotype insights of high-THC medicinal Cannabis sativa L.: the role of SSR markers in the identification of cultivars. [PDF]

J Cannabis Res
Gomes AP, Vicente S, Rosa J, Vinhas I, da Costa AM, Sassano M, Rodrigues LM, Rijo P, Trindade H, Céu Costa MD.   +9 more
europepmc   +1 more source

Heterologous Production of Forskolin in Tobacco (Nicotiana tabacum) via Glandular Trichome Specific Engineering and Metabolic Flux Redirection

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1548-1563, March 2026.
ABSTRACT Plants are promising bioreactor for the sustainable and scalable production of high‐value natural bioactive compounds, because they can synthesise phytochemicals from CO2, light, water and minerals through their innate photosynthetic carbon assimilation machinery.
Xuan Sun, Xiuming Wu, Xun Jiang, Hongmei Huang, Aiguo Yang, Yiting Li, Zhenjun Fan, Aixia Chang, Changqing Yang   +8 more
wiley   +1 more source

Legislating novel psychoactive substances: lessons from 15 years of UK mortality data (2007-2022). [PDF]

Front Pharmacol
Rock KL, Treble R, Copeland CS.
europepmc   +1 more source

Clinical guidelines highlight for the hospitalist: Management of cyclic vomiting syndrome in children

Journal of Hospital Medicine, Volume 21, Issue 3, Page 291-293, March 2026.
Yamileth N. Hernandez, Hannah M. Gardner
wiley   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source