Results 41 to 50 of about 77,790 (265)

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Characteristics of Canadians who use vaping products, by smoking status: findings from the Canadian Community Health Survey, 2020

Health Promotion and Chronic Disease Prevention in Canada
IntroductionTo date, surveillance of vaping among Canadians (using vaping products with or without nicotine) has largely been examined with respect to age and smoking status.
Christine D. Czoli, Camille Guertin, Daniel Dubois, Nancy Farrell, Gabriella Luongo, Gillian Williams, Trevor Mischki   +6 more
doaj   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Mapping and characterization of a novel powdery mildew resistance locus (PM2) in Cannabis sativa L.

Frontiers in Plant Science
IntroductionBreeding genetic resistance to economically important crop diseases is the most sustainable strategy for disease management and enhancing agricultural and horticultural productivity, particularly where the application of synthetic pesticides ...
Soren Seifi, Keegan M. Leckie, Ingrid Giles, Taylor O’Brien, John O. MacKenzie, Marco Todesco, Loren H. Rieseberg, Gregory J. Baute, Jose M. Celedon   +8 more
doaj   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, EarlyView.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source

Determination of THC and THC‐COOH in Dried Capillary Blood Spots and Comparison to Venous Blood of Recreational Cannabis Consumers in a Pilot Study

Drug Testing and Analysis, EarlyView.
A new extraction method was developed and validated for the extraction of THC and THC‐COOH from capillary blood samples collected as dried blood spots. The extracts were analysed using HPLC–MS/MS resulting in high extraction efficiencies for both THC and THC‐COOH.
Matthias Bantle, Willi Schirmer, Joel Bruegger, Thomas Wüthrich, Andreas Längin, Lena Zwicker, Reto Auer, Wolfgang Weinmann   +7 more
wiley   +1 more source

Cannabis Contaminants Limit Pharmacological Use of Cannabidiol

Frontiers in Pharmacology, 2020
For nearly a century, Cannabis has been stigmatized and criminalized across the globe, but in recent years, there has been a growing interest in Cannabis due to the therapeutic potential of phytocannabinoids.
Zackary Montoya, Matthieu Conroy, Brian D. Vanden Heuvel, Christopher S. Pauli, Sang-Hyuck Park, Sang-Hyuck Park   +5 more
doaj   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

Integrating cannabis and gaming: re-evaluating their business intersection

Journal of Cannabis Research
This paper examines the intersection of cannabis and gaming laws in the United States. A particular emphasis is placed on Nevada for its recognition as a leader in the gaming and cannabis industry.
Riana Durrett, Juliana Ness, Marla Royne Stafford, Margaret McLetchie, Jordyn Sanders   +4 more
doaj   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source