Results 131 to 140 of about 38,364 (253)

Pharmacotherapy for Cannabis Use Disorder: Preclinical and Clinical Models. [PDF]

Curr Top Behav Neurosci
Bedillion MF, Moore CF, Weerts EM, Arout CA, Harris HM, Haney M.   +5 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Trends in cannabis use and cannabis use disorder among parents in the U.S., 2012-2024. [PDF]

Addict Behav
Dontha M, Chitty TC, Waddell JT, Kemp EC, Patel H, Pelham WE.   +5 more
europepmc   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Nationwide outcomes of cardiac surgery in patients with cannabis use disorder. [PDF]

J Cardiothorac Surg
Dewan KC, Mahboubi R, Xu S, Maigrot JA, An C, Zhou G, Ferre JLD, Koroukian SM, Weiss AJ, Soltesz EG.   +9 more
europepmc   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Psychiatrists' opinions about non-medicalization of cannabis use disorder in Iran. [PDF]

Discov Ment Health
Namazi H, Sayyah M.
europepmc   +1 more source

Parents With Substance Use Disorder in the Holding Tight Treatment System: Intervention Effectiveness and Moderating Effects

Child &Family Social Work, EarlyView.
ABSTRACT Parents with substance use disorder have multiple risks affecting their parenting. Mental health problems and adverse childhood experiences (ACEs) with problems in emotion regulation and adult attachment insecurity may impair the early interaction with the infant.
Saara J. Salo, Marjo Flykt, Yan Li, Mirjam Kalland, Marjukka Pajulo   +4 more
wiley   +1 more source

Trends in cannabis use disorder and treatment by race and ethnicity, 2002-2019. [PDF]

Front Psychiatry
Triguero Roura M, Vora A, Eschliman EL, Mauro PM.   +3 more
europepmc   +1 more source

Pharmacological and non‐pharmacological interventions for managing sleep disorders in children with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
xxxxxx Aim To systematically review the effectiveness, safety, and economic evidence of pharmacological and non‐pharmacological interventions for sleep disorders in children with cerebral palsy (CP). Method Databases including MEDLINE, Embase, CENTRAL (the Cochrane Library), International Clinical Trials Registry Platform of the World Health ...
Nishant Jaiswal, Lizzie Fisher, Giorgio Ciminata, Ryan Mulholland, Anna Noel‐Storr, Lesley Nutton, Valerie Orr, Paul Eunson, Nicola J. Cooper, Alex Sutton, Olivia Wu, Terry Quinn   +11 more
wiley   +1 more source