Results 101 to 110 of about 396,548 (332)
Supplementary Figure 5 from Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth [PDF]
, 2023 Jo Waaler +11 more
openalex +1 more source
Canonical WNT signaling pathway and human AREG
International Journal of Molecular Medicine, 2006 AREG (Amphiregulin), BTC (beta-cellulin), EGF, EPGN (Epigen), EREG (Epiregulin), HBEGF, NRG1, NRG2, NRG3, NRG4 and TGFA (TGFalpha) constitute EGF family ligands for ERBB family receptors. Cetuximab (Erbitux), Pertuzumab (Omnitarg) and Trastuzumab (Herceptin) are anti-cancer drugs targeted to EGF family ligands, while Gefitinib (Iressa), Erlotinib ...
Yuriko, Katoh, Masaru, Katoh
openaire +3 more sources
Msx2 Exerts Bone Anabolism via Canonical Wnt Signaling [PDF]
Journal of Biological Chemistry, 2008 Msx2 is a homeodomain transcription factor first identified in craniofacial bone and human femoral osteoblasts. We hypothesized that Msx2 might activate skeletal Wnt signaling. Therefore, we analyzed the effects of CMV-Msx2 transgene (Msx2Tg) expression on skeletal physiology and composition.
Su-Li, Cheng +4 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach +7 more
wiley +1 more source
Genes and DiseasesThe evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non ...
Michael Yu +18 more
doaj +1 more source
Non‐canonical Wnt signaling during liver regeneration
The FASEB Journal, 2011 Wnt signaling plays a central role in many processes during hepatic development and in adult liver homeostasis. Two distinct Wnt signaling pathways, the canonical and the non‐canonical pathway, have been described. Since the canonical Wnt/β‐catenin activation during liver regeneration has been previously identified and it has been demonstrated that non‐
Cusimano Antonella +2 more
openaire +2 more sources
Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis [PDF]
BMC Immunology, 2006 AbstractBackgroundThe early B lymphopoiesis in mammals is regulated through close interactions with stromal cells and components of the intracellular matrix in the bone marrow (BM) microenvironment. Although B lymphopoiesis has been studied for decades, the factors that are implicated in this process, both autocrine and paracrine, are inadequately ...
Funderud Steinar +5 more
openaire +3 more sources
Tailored Xenogeneic‐Free Polymer Surface Promotes Dynamic Migration of Intestinal Stem Cells
Advanced Materials, EarlyView.This study introduces a PoLymer‐coated Ultra‐stable Surface (PLUS), a nitrogen plasma‐treated poly(ethyleneglycoldimethacrylate), as a stable xenogeneic‐free platform for intestinal stem cell culture. PLUS enhances cell attachment, supports actin‐driven migration, and retains functionality after 3 years of storage. Promoting cytoskeletal reorganization,
Seonghyeon Park +13 more
wiley +1 more source
Diabetes & vascular disease research, 2017 Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems.
I. Ackers, R. Malgor
semanticscholar +1 more source
Advanced Science, EarlyView.In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo +6 more
wiley +1 more source