Results 121 to 130 of about 75,163 (297)
A gust of WNT: analysis of the canonical WNT pathway.
Acta bio-medica : Atenei Parmensis, 2009 The Wnt pathway is a signal-transduction cascade that mediates communication between cells; the Wnt pathway is involved in key steps during embryological development and in the maintenance of adult tissue homeostasis. Mutational dysregulation of Wnt cascade components has been observed in diverse human pathological conditions and in oncogenic ...
openaire +2 more sources
Canonical Wnt Signaling: An Unexpected New Player [PDF]
Developmental Cell, 2006 Canonical Wnt signaling, below the Fz/LRP receptor complex, induces the stabilization of beta-catenin via an unresolved mechanism. A recent study in Genes & Development introduces a new player and deepens our understanding of this signaling relay that plays pivotal roles during embryogenesis and tumorigenesis.
openaire +2 more sources
CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors
Advanced Science, EarlyView.Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen +12 more
wiley +1 more source
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling [PDF]
, 2007 Wnt signaling controls a wide range of developmental processes and its aberrant regulation can lead to disease. To better understand the regulation of this pathway, we identified zebrafish homologues of Naked Cuticle (Nkd), Nkd1 and Nkd2, which have ...
Coffey, Robert J. +2 more
core +1 more source
Advanced Science, EarlyView.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]
, 2008 [eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core
Sfrp5 and canonical Wnt signalling. [PDF]
, 2019 Effect of different concentrations of Sfrp5 on markers and target genes of the canonical Wnt-signalling pathway: (A) protein levels of the active form of the non-phospho β-catenin (92 kDa) (N = 5), (B) mRNA levels of the transcription factor 7-like 2 ...
Christian Herder (44905) +6 more
core +1 more source
ACTIVITY OF CANONICAL WNT SIGNAL SYSTEM IN HYALINE CARTILAGE ARTICULAR CHONDROCYTES IN PROCESS OF SYNOVIAL JOINT DEVELOPMENT [PDF]
Саратовский научно-медицинский журнал, 2009 Canonical and non-canonical Wnt systems are essential regulators of chondrogenesis and bone development. However, the roles of these systems in synovial joint development are not well studied.
A.O. Molotkov, S.L. Kuznetsov
doaj
CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning
Advanced Science, EarlyView.CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang +11 more
wiley +1 more source
Posteriorizing factor Gbx2 is a direct target of Wnt signalling during neural crest induction [PDF]
, 2015 Wnt signalling is required for neural crest induction; however the direct targets of the Wnt pathway during neural crest induction remain unknown. I show here that the homeobox gene Gbx2 is essential in this process and is directly activated by Wnt/β ...
Li, B
core