Results 131 to 140 of about 396,548 (332)
ACTIVITY OF CANONICAL WNT SIGNAL SYSTEM IN HYALINE CARTILAGE ARTICULAR CHONDROCYTES IN PROCESS OF SYNOVIAL JOINT DEVELOPMENT [PDF]
Саратовский научно-медицинский журнал, 2009 Canonical and non-canonical Wnt systems are essential regulators of chondrogenesis and bone development. However, the roles of these systems in synovial joint development are not well studied.
A.O. Molotkov, S.L. Kuznetsov
doaj
TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia [PDF]
, 2023 Teppei Sakoda +8 more
openalex +1 more source
Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage
Current Molecular Pharmacology, 2019 Background:The ancient and highly evolutionarily conserved Wnt signaling pathway is critical in nearly all tissues and organs for an organism to develop normally from embryo through adult. Wnt signaling is generally parsed into “canonical” or Wnt-β-catenin-dependent or “non-canonical” β-catenin-independent signaling.
Lai, Keane K.Y. +6 more
openaire +3 more sources
Advanced Science, EarlyView.This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing +10 more
wiley +1 more source
Translational Oncology, 2019 Mesenchymal stromal cells (hMSCs) are key components of the bone marrow microenvironment (BMM). A molecular signature in hMSCs from Acute myeloid leukemia patients (hMSC-AML) has been proposed where BMP4 is decreased and could be regulated by WNT ...
Pedro L. Azevedo +5 more
doaj +1 more source
Advanced Science, EarlyView.Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng +9 more
wiley +1 more source
Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage
Oncogenesis, 2017 Frizzled receptors are the mediators of the wnt canonical and non-canonical pathways, which play fundamental roles in cell differentiation and organism development.
G. Corda, G. Corda, Arturo Sala
semanticscholar +1 more source
Interplay of miRNAs and Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma
Frontiers in Pharmacology, 2018 Hepatocellular carcinoma is one of the leading causes of cancer death worldwide and the activation of canonical Wnt signaling pathway is universal in hepatocellular carcinoma patients.
Xiaobo Nie +5 more
doaj +1 more source
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway [PDF]
, 2020 Rilin Deng +26 more
openalex +1 more source