Results 41 to 50 of about 13,092 (226)

Dissociation between AKAP3 and PKARII promotes AKAP3 degradation in sperm capacitation. [PDF]

PLoS ONE, 2013
Ejaculated spermatozoa must undergo a series of biochemical modifications called capacitation, prior to fertilization. Protein-kinase A (PKA) mediates sperm capacitation, although its regulation is not fully understood.
Pnina Hillman, Debby Ickowicz, Ruth Vizel, Haim Breitbart   +3 more
doaj   +1 more source

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

Membrane Potential Assessment by Fluorimetry as a Predictor Tool of Human Sperm Fertilizing Capacity

Frontiers in Cell and Developmental Biology, 2020
Mammalian sperm acquire the ability to fertilize eggs by undergoing a process known as capacitation. Capacitation is triggered as the sperm travels through the female reproductive tract.
Carolina Baro Graf, Carolina Baro Graf, Carla Ritagliati, Valentina Torres-Monserrat, Cintia Stival, Carlos Carizza, Mariano G. Buffone, Dario Krapf, Dario Krapf   +8 more
doaj   +1 more source

Low‐Level Human Epididymis Protein 4 in Seminal Plasma Is an Independent Risk Factor for Poor Semen Liquefaction: A Case Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
Our work identifies a novel and significant association between low seminal levels of Human Epididymis Protein 4 (HE4) and the clinical condition of poor semen liquefaction, a common cause of male infertility. The findings are statistically robust, clinically relevant, and provide a foundational basis for future research into the mechanism by which HE4
Feifei Wang, Jiangnan Wu, Shijie Gao, Zhuohan Zheng, Zhiheng Wang, Jing Gao   +5 more
wiley   +1 more source

Universities and institutionalization of regional innovation policy in peripheral regions: Insights from the smart specialization in Portugal

Regional Science Policy &Practice, EarlyView., 2023
Abstract Regional innovation policies are currently influenced by a series of territorial innovation models, with the regional innovation system (RIS) approach being one of the prominent examples. The rationale of smart specialization strategies (S3s) is deeply influenced by the RIS concept and highlights the importance of entrepreneurial discovery and
Hugo Pinto
wiley   +1 more source

The ABCA1 blocking agent probucol decreases capacitation in ejaculated dog spermatozoa

Acta Veterinaria Scandinavica, 2020
Background The ATP binding cassette (ABC) transporters participate in the cholesterol and phospholipid transport within and through cell membranes of many cells including spermatozoa. Cholesterol efflux is important for capacitation of spermatozoa. ABCA1
Sabine Schäfer-Somi, Sven Budik
doaj   +1 more source

Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens)

Frontiers in Physiology, 2022
Mammalian spermatozoa are not mature after ejaculation and must undergo additional functional and structural changes within female reproductive tracts to achieve subsequent fertilization, including both capacitation and acrosome reaction (AR), which are ...
Renzheng Zhang, Renzheng Zhang, Chunnian Liang, Xian Guo, Pengjia Bao, Jie Pei, Fude Wu, Mancai Yin, Min Chu, Ping Yan   +9 more
doaj   +1 more source

Global meta‐analysis reveals urban‐associated behavioural differences among wild populations

Journal of Animal Ecology, EarlyView.
Urbanization drives rapid phenotypic change, yet broad patterns of behavioural responses remain unclear. Using a global phylogenetic meta‐analysis, we show urban populations exhibit increased boldness, aggression, exploration and activity—especially in birds—highlighting consistent behavioural shifts and revealing major taxonomic gaps that limit our ...
Tracy T. Burkhard, Ned A. Dochtermann, Anne Charmantier   +2 more
wiley   +1 more source

Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction

Reproductive Biology and Endocrinology, 2004
Capacitation is an important physiological pre-requisite before the sperm cell can acrosome react and fertilize the oocyte. Recent reports from several laboratories have amply documented that the protein phosphorylation especially at tyrosine residues is
Rajesh Preeti B, Naz Rajesh K
doaj   +1 more source

Inhibiting sperm pyruvate dehydrogenase complex and its E3 subunit, dihydrolipoamide dehydrogenase affects fertilization in Syrian hamsters. [PDF]

PLoS ONE, 2014
BACKGROUND/AIMS: The importance of sperm capacitation for mammalian fertilization has been confirmed in the present study via sperm metabolism.
Archana B Siva, Subbarayalu Panneerdoss, Purnima Sailasree, Durgesh K Singh, Duvurri B Kameshwari, Sisinthy Shivaji   +5 more
doaj   +1 more source