Results 31 to 40 of about 13,419 (163)

A special perspective on human fertilization: The role of sperm capacitation proteins and channels: A narrative review

International Journal of Reproductive BioMedicine
Sperm undergo a last step of maturation known as capacitation in the female reproductive system, which prepares themselves to fertilize the ovum. Mechanisms of capacitation include changes in membrane composition, electrolyte concentration, pH levels ...
Nasrin Malverdi, Sheida Kazemi, Negin Tavakoli, Mohammad Reza Deemeh, Mehdi Abedinzadeh, Serajoddin Vahidi, Peyman Salehi   +6 more
doaj   +1 more source

Exogenous Albumin Is Crucial for Pig Sperm to Elicit In Vitro Capacitation Whereas Bicarbonate Only Modulates Its Efficiency

Biology, 2021
This work sought to address whether the presence of exogenous bicarbonate is required for pig sperm to elicit in vitro capacitation and further progesterone-induced acrosome exocytosis. For this purpose, sperm were either incubated in a standard in vitro
Bruna Resende Chaves, Ana Paula Pinoti Pavaneli, Olga Blanco-Prieto, Elisabeth Pinart, Sergi Bonet, Márcio Gilberto Zangeronimo, Joan E. Rodríguez-Gil, Marc Yeste   +7 more
doaj   +1 more source

Membrane Potential Assessment by Fluorimetry as a Predictor Tool of Human Sperm Fertilizing Capacity

Frontiers in Cell and Developmental Biology, 2020
Mammalian sperm acquire the ability to fertilize eggs by undergoing a process known as capacitation. Capacitation is triggered as the sperm travels through the female reproductive tract.
Carolina Baro Graf, Carolina Baro Graf, Carla Ritagliati, Valentina Torres-Monserrat, Cintia Stival, Carlos Carizza, Mariano G. Buffone, Dario Krapf, Dario Krapf   +8 more
doaj   +1 more source

The ABCA1 blocking agent probucol decreases capacitation in ejaculated dog spermatozoa

Acta Veterinaria Scandinavica, 2020
Background The ATP binding cassette (ABC) transporters participate in the cholesterol and phospholipid transport within and through cell membranes of many cells including spermatozoa. Cholesterol efflux is important for capacitation of spermatozoa. ABCA1
Sabine Schäfer-Somi, Sven Budik
doaj   +1 more source

Dissociation between AKAP3 and PKARII promotes AKAP3 degradation in sperm capacitation. [PDF]

PLoS ONE, 2013
Ejaculated spermatozoa must undergo a series of biochemical modifications called capacitation, prior to fertilization. Protein-kinase A (PKA) mediates sperm capacitation, although its regulation is not fully understood.
Pnina Hillman, Debby Ickowicz, Ruth Vizel, Haim Breitbart   +3 more
doaj   +1 more source

Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens)

Frontiers in Physiology, 2022
Mammalian spermatozoa are not mature after ejaculation and must undergo additional functional and structural changes within female reproductive tracts to achieve subsequent fertilization, including both capacitation and acrosome reaction (AR), which are ...
Renzheng Zhang, Renzheng Zhang, Chunnian Liang, Xian Guo, Pengjia Bao, Jie Pei, Fude Wu, Mancai Yin, Min Chu, Ping Yan   +9 more
doaj   +1 more source

Inhibiting sperm pyruvate dehydrogenase complex and its E3 subunit, dihydrolipoamide dehydrogenase affects fertilization in Syrian hamsters. [PDF]

PLoS ONE, 2014
BACKGROUND/AIMS: The importance of sperm capacitation for mammalian fertilization has been confirmed in the present study via sperm metabolism.
Archana B Siva, Subbarayalu Panneerdoss, Purnima Sailasree, Durgesh K Singh, Duvurri B Kameshwari, Sisinthy Shivaji   +5 more
doaj   +1 more source

Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction

Reproductive Biology and Endocrinology, 2004
Capacitation is an important physiological pre-requisite before the sperm cell can acrosome react and fertilize the oocyte. Recent reports from several laboratories have amply documented that the protein phosphorylation especially at tyrosine residues is
Rajesh Preeti B, Naz Rajesh K
doaj   +1 more source

Regulation of Sperm Capacitation and the Acrosome Reaction by PIP 2 and Actin Modulation

Asian Journal of Andrology, 2015
Actin polymerization and development of hyperactivated (HA) motility are two processes that take place during sperm capacitation. Actin polymerization occurs during capacitation and prior to the acrosome reaction, fast F-actin breakdown takes place.
Haim Breitbart, Maya Finkelstein
doaj   +1 more source

Bottom-up approach to deciphering the targets of the ubiquitin-proteasome system in porcine sperm capacitation

Scientific Reports
Capacitation is an essential post-testicular maturation event endowing spermatozoa with fertilizing capacity within the female reproductive tract, significant for fertility, reproductive health, and contraception.
Michal Zigo, Jacob Netherton, Natálie Zelenková, Karl Kerns, Veronika Kraus, Pavla Postlerová, Mark Baker, Peter Sutovsky   +7 more
doaj   +1 more source