Results 131 to 140 of about 76,053 (241)

Use of capecitabine in management of early colon cancer

Cancer Management and Research, 2011
H Hameed, J CassidyBeatson West of Scotland Cancer Centre, Glasgow, Scotland, UKAbstract: Capecitabine (Xeloda®, Roche, Basel, Switzerland) is a pro-drug of 5-fluorouracil (5-FU), and it is converted to 5-FU in the cancer cell by enzymatic ...
Cassidy J, Hameed H
doaj  

Metronomic Capecitabine Triggers Ferroptosis in Hepatocellular Carcinoma Cells Through Inhibition of TYMS

Cancer Medicine, Volume 15, Issue 5, May 2026.
In the syngeneic tumor mouse model, capecitabine inhibits TYMS by metabolizing to 5‐fluorouracil in vivo, which leads to the activation of intracellular NOX. The massive release of ROS leads to the accumulation of ferrous ions in mitochondria, and the imbalance of intracellular oxidative stress and the accumulation of ferrous ions cause ferroptosis of ...
Ruining Yang, Yuan Chang, Zhan Feng, Jiaowen Yang, Qian Sun, Hao Wang, Dejun Kong, Jinliang Duan, Shaofeng Chen, Lei Cao, Jiashu Ren, Sei Yoshida, Zhenglu Wang, Hong Zheng   +13 more
wiley   +1 more source

Visualized Clinical‐Radiomics Model Based on Non‐Contrast Computed Tomography for Predicting Efficacy of Surufatinib in Hepatic Metastases of Neuroendocrine Neoplasms

Cancer Medicine, Volume 15, Issue 5, May 2026.
NCCT radiomics for surufatinib efficacy prediction in HM‐NENs. ABSTRACT Background Hepatic metastatic neuroendocrine neoplasms (HM‐NENs) have few treatment biomarkers and low survival rates. We created a clinical‐radiomics fusion model based on non‐contrast computed tomography (NCCT) to predict Surufatinib efficacy in HM‐NENs.
Miaomiao Feng, Man Zhao, Xiaoling Duan, Jiaojiao Hou, Qi Wang, Fei Yin   +5 more
wiley   +1 more source

Multicenter Real‐World Evaluation of Neoadjuvant Carboplatin in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background The role of carboplatin in neoadjuvant chemotherapy for triple‐negative breast cancer (TNBC) remains controversial, particularly in settings where access to immunotherapy is limited. This study evaluated the real‐world impact of adding carboplatin to neoadjuvant chemotherapy on pathological complete response (pCR) and survival ...
Halil İbrahim Ellez, Eda ÇalişkanYildirim, Nargiz Majidova, Yeşim Ağyol, Murat Sarı, Hüseyin Salih Semiz, Oktay Halit Aktepe, Olçun Umit Unal, Elif Atağ   +8 more
wiley   +1 more source

[Comment] Total neoadjuvant treatment with short-course radiotherapy followed by sintilimab plus capecitabine-oxaliplatin versus short-course radiotherapy followed by capecitabine-oxaliplatin in patients with locally advanced rectal cancer (SPRING-01): a single-centre, open-label, phase 2, randomised controlled trial

结直肠肛门外科
[Background] Neoadjuvant short-course radiotherapy combined with chemotherapy as total neoadjuvant therapy increases the pathological complete response rate for patients with locally advanced rectal cancer.
Li You
doaj   +1 more source

Prognostic Value and Therapeutic Implications of MRI‐Based Negative Lymph Nodes in Nasopharyngeal Carcinoma

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background This study aimed to evaluate the prognostic significance of negative lymph nodes (LNnegs) identified by magnetic resonance imaging (MRI) and treatment implications in patients with N0 locoregionally advanced NPC. Methods This retrospective cohort study included 753 patients with T3–4N0M0 NPC receiving concurrent chemoradiotherapy ...
Ze‐Qi Lin, Chu‐Yu He, Shui‐Qing He, Dong‐Yu Dai, Kai‐Bin Yang, Ji‐Bin Li, Li‐Zhi Liu, Ying Huang, Yuan Zhang, Xu Liu, Jun Ma, Jia‐Ni Liu, Cheng Xu   +12 more
wiley   +1 more source

Preoperative Biomarker Panel With Fibrinogen, FVIII, and CA 19–9 as a Tool for Prognostic Evaluation in Neoadjuvant‐Treated Pancreatic Ductal Adenocarcinoma

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) is highly thrombogenic and lethal, with rising incidence. Combining carbohydrate antigen (CA) 19–9, fibrinogen, coagulation factor VIII (FVIII), albumin, and alkaline phosphatase (ALP) as a diagnostic panel improves diagnostics.
Nora Mattila, Riitta Lassila, Harri Mustonen, Caj Haglund, Hanna Seppänen   +4 more
wiley   +1 more source

Feasibility Study of Trifluridine/Tipiracil and Zolbetuximab as Third‐ or Later‐Line Chemotherapy for CLDN18.2‐Positive and HER2‐Negative Gastric or Gastroesophageal Junction Adenocarcinoma: A Study Protocol

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Zolbetuximab is an anti‐claudin18.2 (CLDN18.2) antibody, and the addition of zolbetuximab in combination with fluoropyrimidine and oxaliplatin as a first‐line treatment for CLDN18.2‐positive and HER2‐negative gastric or gastroesophageal junction adenocarcinoma has been shown to improve survival.
Osamu Maeda, Chie Tanaka, Kazuhiro Furukawa, Kazushi Miyata, Dai Shimizu, Shizuki Sugita, Koki Nakanishi, Takashi Hirose, Kazuyuki Mizuno, Fumie Kinoshita, Yachiyo Kuwatsuka, Masahiko Ando, Mitsuro Kanda, Hiroki Kawashima, Yuichi Ando   +14 more
wiley   +1 more source

When Carcinoma Meets Sarcoma: A Rare Case of Pancreatic Carcinosarcoma and Review of Literature

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Pancreatic carcinosarcoma is an extremely rare and aggressive malignancy with both epithelial and mesenchymal components. This case contributes to the limited global literature, emphasizing the importance of awareness, accurate diagnosis, and further research to improve understanding and management of this lethal tumor.
Pouria Abedini, Behnam Sanei, Ali Hajihashemi, Maryam Sanei, Alireza Firouzfar   +4 more
wiley   +1 more source

MRI Based Radiomics as an Imaging Biomarker for Locally Advanced Carcinoma Rectum: Predicting Tumor Response Following Neoadjuvant Chemoradiotherapy as an Organ Preservation Strategy

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Patients with locally advanced rectal cancer show variable responses to neoadjuvant chemoradiotherapy (NACTRT), making early prediction of treatment response clinically important. Radiomics and machine learning may offer a potential non‐invasive imaging biomarker to identify patients who are more likely to respond to treatment.
Abhinav Puppalwar, Reena Engineer, Ashish Kumar Jha, Shivakumar Gudi, Rahul Krishnartry, Prashant Nayak, Jai Prakash Agarwal, Jayant S. Goda   +7 more
wiley   +1 more source