Results 121 to 130 of about 67,411 (205)

Multinuclear NMR Measurements and DFT Calculations for Capecitabine Tautomeric Form Assignment in a Solution

Molecules, 2018
The molecular structure of capecitabine (a widely applied prodrug of 5-fluorouracil) was studied by multinuclear NMR measurements and DFT quantum mechanical calculations.
Piotr Cmoch, Piotr Krzeczyński, Andrzej Leś   +2 more
doaj   +1 more source

Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells

bioRxiv, 2019
Background Myeloid-derived suppressor cells (MDSCs) are elevated in glioblastoma (GBM) patient circulation, present in tumor tissue, and associated with poor prognosis.
D. Peereboom, T. Alban, Matthew M. Grabowski, Alvaro G. Alvarado, B. Otvos, Defne Bayik, G. Roversi, Mary McGraw, Pengjing Huang, A. Mohammadi, H. Kornblum, T. Radivoyevitch, M. Ahluwalia, M. Vogelbaum, J. Lathia   +14 more
semanticscholar   +1 more source

Oxaliplatin‐induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose–response relationship and impact on quality of life

International Journal of Cancer, Volume 159, Issue 1, Page 198-209, 1 July 2026.
What's New? Oxaliplatin serves a key role in the treatment of rectal cancer, though it is a significant cause of chemotherapy‐induced peripheral neuropathy. As total neoadjuvant therapy, in which all therapy is given before surgery, has become more common, understanding neuropathy has grown increasingly important. This study examined neuropathy and its
Georg W. Wurschi, Andreas Hinz, Melanie Schneider, Jan‐Niklas Becker, Bernd Frerker, Samuel M. Vorbach, Felix Ehret, Markus Diefenhardt, Fabian Schunn, Maria‐Elena von Gruben, Marcel Büttner, Elgin Hoffmann, Alexander Rühle, Josephine Beier, Simone Ferdinandus, Maike Trommer, Ezgi Ceren Sahin, Julian Hlouschek, Kynann Aninditha, Daphne Schepers von Ohlen, Justus Kaufmann, Alina Depardon, Hai Minh Ha, Christopher Kessler, Adrianna Cieslak, Simon Trommer, Alexander Fabian, Florian Rißner, Maximilian Römer, Klaus Pietschmann   +29 more
wiley   +1 more source

Real‐world progression‐free survival and overall survival in patients with HR+/HER2− advanced breast cancer treated in first‐line with ribociclib, endocrine monotherapy or chemotherapy: Results from the observational RIBANNA study

International Journal of Cancer, Volume 159, Issue 1, Page 210-223, 1 July 2026.
What's New? The CDK4/6 inhibitor ribociclib in combination with an endocrine‐based therapy has demonstrated significant progression‐free and overall survival benefits in patients with advanced/metastatic HR+/HER2‐ breast cancer in the pivotal MONALEESA trials.
Peter A. Fasching, Cosima Brucker, Thomas Decker, Anne Engel, Thomas Göhler, Christian Jackisch, Jan Janssen, Andreas Köhler, Kerstin Lüdtke‐Heckenkamp, Diana Lüftner, Frederik Marmé, Marion van Mackelenbergh, Beate Rautenberg, Marcus Schmidt, Rudolf Weide, Pauline Wimberger, Elena Kisseleff, Christina Pfister, Claudia Quiering, Christian Roos, Achim Wöckel   +20 more
wiley   +1 more source

Safety and Efficacy of a Sandwich Total Neoadjuvant Therapy Strategy for Low‐Risk Distal Locally Advanced Rectal Cancer: Results From the TESS Phase II Trial

MedComm, Volume 7, Issue 7, July 2026.
The proposed sandwich total neoadjuvant treatment (TNT) strategy (NeoCT–CRT–NeoCT) represents a safe and effective therapeutic option for carefully selected patients with low‐risk distal locally advanced rectal cancer (LARC). By sequentially integrating induction chemotherapy, concurrent chemoradiotherapy, and consolidation chemotherapy, this approach ...
Shuang Liu, GuangZhao Lv, GeYu Xu, XiaoZhong Wang, YeZhong Zhuang, ShouMin Bai, HaiNa Yu, XiaoJun Wu, YiJing Ye, HuiLong Luo, ShuoYu Xu, QiaoXuan Wang, Hui Chang, PeiQiang Cai, ZhiZhong Pan, YuanHong Gao, Gong Chen, WeiWei Xiao   +17 more
wiley   +1 more source

Diagnostic Impact of Liver Biopsy Among Antinuclear Antibody Positive Individuals With Mild Liver Enzyme Elevation

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 103-111, July 2026.
In ANA‐positive patients with suspected autoimmune hepatitis (AIH), liver biopsy rarely altered therapeutic management when alanine aminotransferase (ALT) was below 101 U/L and cirrhosis was absent. These findings suggest that biopsy may be safely deferred in this low‐risk group.
David Mehdi Asgher Niazi, Alphonse Charbel, Jan Pfeiffenberger, Uta Merle, Jessica Seessle, Theresa Wenz, Christa Flechtenmacher, Patrick Michl, Conrad Rauber   +8 more
wiley   +1 more source

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2‐p53 Pathway and M2 Macrophage Polarization

Cancer Science, Volume 117, Issue 7, Page 1813-1827, July 2026.
SLC1A3 promotes colorectal cancer progression by transporting extracellular aspartate into tumor cells, thereby activating the PKC/MDM2/p53 pathway to enhance proliferation. Reduced extracellular aspartate, combined with p53‐dependent suppression of CSF2 and IL17C, drives M2 macrophage polarization via immune modulation, macrophage recruitment, and M2 ...
Chao Deng, You Zhou, Sijie Song, Hongtao Liu, Siqi Liao, Li Zhou, Siyuan Chen, Zhihang Zhou, Song He, Bingrong Liu   +9 more
wiley   +1 more source

Executive summary of American Radium Society Appropriate Use Criteria for the treatment of locoregionally recurrent rectal cancer

Cancer, Volume 132, Issue 12, 15 June 2026.
Abstract This literature‐based systematic review and associated guidelines provide evidence‐based paradigms for the management of locoregionally recurrent rectal cancer (LRRC). This multispecialty committee included gastrointestinal radiation and medical oncology, gastroenterology, radiology, and colorectal surgery.
Eric D. Miller, Krishan R. Jethwa, Eric Dozois, Zhaohui Jin, Gerard Abood, Dmitriy Akselrod, Joseph Attallah, D. Chamil Codipilly, Christopher J. Anker, Christopher L. Hallemeier, Leslie C. Hassett, Timothy Kennedy, Percy Lee, Diane C. Ling, Neil B. Newman, Navesh Sharma, William Small Jr., Leila Tchelebi, Suzanne Russo   +18 more
wiley   +1 more source

A pilot study investigating plasma pharmacokinetics and tolerance of oral capecitabine in carcinoma-bearing dogs

BMC Veterinary Research
Background Capecitabine is an oral prodrug of the active metabolite 5-fluorouracil, which has been used effectively in human colorectal, head and neck, and mammary carcinomas.
Sarah Wetzel, Janean Fidel, Dale Whittington, Nicolas F. Villarino   +3 more
doaj   +1 more source

Lapatinib plus capecitabine for HER2-positive advanced breast cancer.

New England Journal of Medicine, 2006
Charles E. Geyer, J. Forster, Deborah L. Lindquist, Stephen Chan, C. Romieu, T. Pieńkowski, A. Jagiełło-Gruszfeld, J. Crown, A. Chan, Bella Kaufman, Dimosthenis Skarlos, M. Campone, N. Davidson, M. Berger, C. Oliva, Stephen D. Rubin, S. Stein, David Cameron   +17 more
semanticscholar   +1 more source