Results 11 to 20 of about 815,985 (386)

Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries

Circulation Research, 2022
Capillaries are equipped to sense neurovascular coupling agents released onto the outer wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a crucial role in blood flow regulation and ensuring that neuronal ...
O. Harraz, Nicholas R. Klug, Amanda J. Senatore, David Hill-Eubanks, M. Nelson   +4 more
semanticscholar   +1 more source

Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Rises in local brain activity are accompanied by increases in blood perfusion, a process known as neurovascular coupling. This relationship constitutes the physiological basis of functional neuroimaging scans, but the exact mechanisms are ...
S. Zambach, Changsi Cai, H. C. Helms, B. Hald, Yiqiu Dong, J. Fordsmann, Reena Murmu Nielsen, Jingshi Hu, Micael Lønstrup, B. Brodin, M. Lauritzen   +10 more
semanticscholar   +1 more source

Molecular transport through capillaries made with atomic-scale precision [PDF]

Nature, 2016
Nanometre-scale pores and capillaries have long been studied because of their importance in many natural phenomena and their use in numerous applications.
B. Radha, A. Esfandiar, F. C. Wang, A. Rooney, K. Gopinadhan, A. Keerthi, A. Mishchenko, A. Janardanan, P. Blake, L. Fumagalli, M. Lozada-Hidalgo, S. Garaj, S. Haigh, I. Grigorieva, H. A. Wu, A.K. Geim   +15 more
semanticscholar   +1 more source

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

Science, 2019
Pericytes put the squeeze on cognition Like a computer, the brain needs a reliable source of power, which is provided as oxygen and glucose in the blood. However, in many neurological disorders this energy supply is disrupted.
R. Nortley, Nils Korte, P. Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Z. Jaunmuktane, V. Kyrargyri, T. Pfeiffer, Lila Khennouf, C. Madry, Hui Gong, A. Richard-Loendt, Wenhui Huang, T. Saito, Takaomi C. Saido, S. Brandner, H. Sethi, D. Attwell   +17 more
semanticscholar   +1 more source

Is the microvasculature tone increasing with arterial hypertension?

Alʹmanah Kliničeskoj Mediciny, 2019
Rationale: An increase in vascular tone is believed to be a major factor leading to arterial hypertension (AH). There are no means for a direct measurement of the vascular tone in clinical practice.
D. A. Rogatkin, P. A. Glazkova, D. A. Kulikov, A. A. Glazkov, S. A. Terpigorev, G. G. Shekhyan, K. A. Kozlova, M. B. Makmatov-Rys   +7 more
doaj   +1 more source

Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats

Frontiers in Aging Neuroscience, 2020
Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long ...
Lin Chen, Lin Chen, Feng-lei Chao, Feng-lei Chao, Wei Lu, Wei Lu, Lei Zhang, Lei Zhang, Chun-xia Huang, Shu Yang, Shu Yang, Xuan Qiu, Xuan Qiu, Hao Yang, Hao Yang, Yuan-yu Zhao, Yuan-yu Zhao, San-rong Wang, Chen Li, Yong Tang, Yong Tang   +20 more
doaj   +1 more source

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

Nature Neuroscience, 2018
Cerebral blood flow (CBF) reductions in Alzheimer’s disease patients and related mouse models have been recognized for decades, but the underlying mechanisms and resulting consequences for Alzheimer’s disease pathogenesis remain poorly understood. In APP/
J. C. Cruz Hernández, O. Bracko, Calvin J. Kersbergen, V. Muse, Mohammad Haft-Javaherian, Maxime Berg, Laibaik Park, Lindsay K. Vinarcsik, Iryna Ivasyk, Daniel A. Rivera, Y. Kang, Marta Cortes-Canteli, Myriam Peyrounette, Vincent Doyeux, Amy Smith, Joan Zhou, G. Otte, Jeffrey D. Beverly, Elizabeth Davenport, Y. Davit, Charles P. Lin, S. Strickland, C. Iadecola, S. Lorthois, N. Nishimura, C. Schaffer   +25 more
semanticscholar   +1 more source

Retinal oxygen supply shaped the functional evolution of the vertebrate eye

eLife, 2019
The retina has a very high energy demand but lacks an internal blood supply in most vertebrates. Here we explore the hypothesis that oxygen diffusion limited the evolution of retinal morphology by reconstructing the evolution of retinal thickness and the
Christian Damsgaard, Henrik Lauridsen, Anette MD Funder, Jesper S Thomsen, Thomas Desvignes, Dane A Crossley II, Peter R Møller, Do TT Huong, Nguyen T Phuong, H William Detrich III, Annemarie Brüel, Horst Wilkens, Eric Warrant, Tobias Wang, Jens R Nyengaard, Michael Berenbrink, Mark Bayley   +16 more
doaj   +1 more source

Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits [PDF]

, 1999
Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage.
Goetz, Alwin Eduard, Groh, Joachim, Kiefmann, Rainer, Kuebler, Wolfgang M., Kuhnle, Gerhard E. H., Sckell, Axel   +5 more
core   +1 more source

ANALYSIS OF ENDOPLASMIC RETICULUM OF TOBACCO CELLS USING CONFOCAL MICROSCOPY

Image Analysis and Stereology, 2011
Image analysis techniques for preprocessing, segmentation and estimation of geometrical characteristics of fiber-like structures from 2-D or 3-D images captured by a confocal microscope are presented.
Barbora Radochová, Jiří Janáček, Kateřina Schwarzerová, Erna Demjénová, Zoltán Tomori, Petr Karen, Lucie Kubínová   +6 more
doaj   +1 more source