Results 41 to 50 of about 349,942 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural Microangiopathies in Skeletal Muscle Related to Systemic Vascular Pathologies in Humans

Frontiers in Physiology, 2020
It is unclear how microangiopathic changes in skeletal muscle vary among systemic vascular pathologies. We therefore analyzed the capillary fine structure in skeletal muscle from patients with arterial hypertension (HYPT), diabetes mellitus type 2 (T2DM)
Oliver Baum, Jonathan Bernd, Samuel Becker, Adolfo Odriozola, Benoît Zuber, Stefan A. Tschanz, Andreas Zakrzewicz, Stuart Egginton, Janine Berkholz   +8 more
doaj   +1 more source

High-resolution imaging of kidney vascular corrosion casts with nano-CT [PDF]

, 2010
A vascular corrosion cast of an entire mouse kidney was scanned with a modular multiresolution X-ray nanotomography system. Using an isotropic voxel pitch of 0.5 mu m, capillary systems such as the vasa recta, peritubular capillaries and glomeruli were ...
Czymmek, Kirk, Hossler, Fred, Pauwels, Elin, Van Hoorebeke, Luc, Van Loo, Denis, Wagner, Roger   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modeling of water rising in hydraulically coupled cylindrical capillaries of different radii

Advanced Engineering Research, 2018
Introduction. Vertical upward flow of water in the plant xylem occurs under the action of the water surface tension in the capillary menisci. In some papers, it is shown that the distribution of water in the inclined capillary systems is subject to the ...
I. A. Kipnis, Yu. M. Vernigorov
doaj   +1 more source

A study of capillaries in equine skeletal muscle : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Anatomy and Physiology at Massey University [PDF]

, 1993
Four horses of varying ages, breeds and sex were used to evaluate the variation in capillary supply and fibre type proportions in a range of equine skeletal muscles. A total of 100 muscles were sampled from the four horses. These samples were stained for
Slassor, Lynn Elizabeth
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

VEGF-A isoforms induce the expression of APLN in endothelial cells during human prenatal lung development

Frontiers in Cell and Developmental Biology
IntroductionSingle-cell RNA-sequencing analyses have revealed the existence of two distinct capillary cell populations in the human lung: general capillary cells (CAP1) and alveolar capillary cells (CAP2). Studies in mouse have shown that the splicing of
Antony Hoarau, Andrew Frauenpreis, Randa Belgacemi, Emma Loeffler, Osshaya Maalouf, Ian A. Glass, Denise Al Alam, Denise Al Alam, Soula Danopoulos, Soula Danopoulos   +9 more
doaj   +1 more source

Evidence of acute inflammation in the periodontal ligament subsequent to orthodontic tooth movement in rats

Australasian Orthodontic Journal, 1989
Experimental orthodontic tooth extrusion can result in red cell diapedesis through the PDL vascular wall. Diapedesis is an early sign of acute inflammation.
Cooper Stephanie M., Sims Milton R.
doaj   +1 more source

Capillary Rogue Waves [PDF]

Physical Review Letters, 2010
We report the first observation of extreme wave events (rogue waves) in parametrically driven capillary waves. Rogue waves are observed above a certain threshold in forcing. Above this threshold, frequency spectra broaden and develop exponential tails.
Shats, Michael, Punzmann, Horst, Xia, Hua   +2 more
openaire   +4 more sources