Expression and tumor-promoting effects of caprin-1 in human glioma
Glioma, 2018 Background: Cytoplasmic activation/proliferation-associated protein-1 (caprin-1) is a newly discovered RNA-binding protein and is now recognized as one of the putative oncogenes.
Li Zhang +9 more
doaj +3 more sources
Role of caprin-1 in carcinogenesis. [PDF]
Oncol Lett, 2019 RNA-binding proteins serve an essential role in post-transcriptional gene regulation. Cytoplasmic activation/proliferation-associated protein-1 (caprin-1) is an RNA-binding protein that participates in the regulation of cell cycle control-associated genes.
Yang ZS +5 more
europepmc +6 more sources
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions. [PDF]
J Proteome Res, 2021 AbstractCytoplasmic stress granules (SGs) are dynamic non-membranous foci containing translationally arrested mRNA and RNA binding proteins that form in response to a variety of cellular stressors. SGs may evolve into the cytoplasmic inclusions observed in many neurodegenerative diseases.
Vu L +10 more
europepmc +5 more sources
Crystal structure of a dimerization domain of human Caprin-1: insights into the assembly of an evolutionarily conserved ribonucleoprotein complex consisting of Caprin-1, FMRP and G3BP1. [PDF]
Acta Crystallogr D Struct Biol, 2016 Caprin-1 plays roles in many important biological processes, including cellular proliferation, innate immune response, stress response and synaptic plasticity. Caprin-1 has been implicated in several human diseases, including osteosarcoma, breast cancer, viral infection, hearing loss and neurodegenerative disorders.
Wu Y, Zhu J, Huang X, Du Z.
europepmc +6 more sources
Yin and yang regulation of stress granules by Caprin-1. [PDF]
Proc Natl Acad Sci U S A, 2022 Stress granules (SGs) are cytoplasmic biomolecular condensates containing proteins and RNAs in response to stress. Ras-GTPase–activating protein binding protein 1 (G3BP1) is a core SG protein. Caprin-1 and ubiquitin specific peptidase 10 (USP10) interact with G3BP1, facilitating and suppressing SG formation, respectively.
Song D +9 more
europepmc +5 more sources
THE ROLE OF CAPRIN-1 PROTEIN DYSREGULATION IN SYNAPSE DECLINE LEADING TO PROGRESSION OF TAUOPATHIES [PDF]
Innov Aging, 2019 Abstract Many neurodegenerative diseases are characterized by accumulation of proteins such as tau, a microtubule stabilization protein. Toxic tau forms tangles and affects neuronal synapse function, an early step of neurodegeneration. To focus on synapse function, we highlighted Caprin-1 protein.
Fastenau C +3 more
europepmc +4 more sources
Bacterial expression and preliminary crystallographic studies of a 149-residue fragment of human Caprin-1. [PDF]
Acta Crystallogr F Struct Biol Commun, 2015 Caprin-1 is an RNA-binding protein which plays critical roles in several important biological processes, including cellular proliferation, the interferon-mediated antiviral innate immune response, the maintenance of synaptic plasticity and the formation of RNA stress granules.
Wu Y, Zhu J, Huang X, Du Z.
europepmc +6 more sources
Figure S6 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>CAPRIN-1 expression on the cell membrane increases due to stressful stimuli to the cancer cells.</p>
Fumiyoshi Okano +13 more
+4 more sources
Figure S5 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>Correlation of CAPRIN-1 expression levels on the cell surface with tumor cell growth in vivo or in vitro.</p>
Fumiyoshi Okano +13 more
+4 more sources
Figure S1 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>Anti-CAPRIN-1 antibodies</p>
Fumiyoshi Okano +13 more
+4 more sources