circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR. [PDF]
Oncogene, 2023 AbstractCircular RNA (circRNA) is a novel RNA molecule characterized by covalently closed loop structure. Since its discovery, researchers have shown that circRNA is not “splicing noise” but a participant of various pathophysiological processes through unique mechanisms.
Liu J, Niu L, Hao J, Yao Y, Yan M, Li H.
europepmc +5 more sources
Expression and tumor-promoting effects of caprin-1 in human glioma
Glioma, 2018 Background: Cytoplasmic activation/proliferation-associated protein-1 (caprin-1) is a newly discovered RNA-binding protein and is now recognized as one of the putative oncogenes.
Li Zhang +9 more
doaj +3 more sources
Bacterial expression and preliminary crystallographic studies of a 149-residue fragment of human Caprin-1. [PDF]
Acta Crystallogr F Struct Biol Commun, 2015 Caprin-1 is an RNA-binding protein which plays critical roles in several important biological processes, including cellular proliferation, the interferon-mediated antiviral innate immune response, the maintenance of synaptic plasticity and the formation of RNA stress granules.
Wu Y, Zhu J, Huang X, Du Z.
europepmc +6 more sources
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1 [PDF]
Nature Communicationsβ-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder caused by mutations in the WDR45 gene, yet its molecular mechanisms remain poorly understood.
Yin Li +16 more
doaj +3 more sources
Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation. [PDF]
J Virol, 2013 ABSTRACT Stress granules (SGs) are cytoplasmic foci composed of stalled translation preinitiation complexes induced by environmental stress stimuli, including viral infection. Since viral propagation completely depends on the host translational machinery, many viruses have evolved to circumvent the induction of SGs or co-opt SG ...
Katoh H +7 more
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THE ROLE OF CAPRIN-1 PROTEIN DYSREGULATION IN SYNAPSE DECLINE LEADING TO PROGRESSION OF TAUOPATHIES [PDF]
Innov Aging, 2019 Abstract Many neurodegenerative diseases are characterized by accumulation of proteins such as tau, a microtubule stabilization protein. Toxic tau forms tangles and affects neuronal synapse function, an early step of neurodegeneration. To focus on synapse function, we highlighted Caprin-1 protein.
Fastenau C +3 more
europepmc +4 more sources
Yin and yang regulation of stress granules by Caprin-1. [PDF]
Proc Natl Acad Sci U S A, 2022 Stress granules (SGs) are cytoplasmic biomolecular condensates containing proteins and RNAs in response to stress. Ras-GTPase–activating protein binding protein 1 (G3BP1) is a core SG protein. Caprin-1 and ubiquitin specific peptidase 10 (USP10) interact with G3BP1, facilitating and suppressing SG formation, respectively.
Song D +9 more
europepmc +3 more sources
Figure S6 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>CAPRIN-1 expression on the cell membrane increases due to stressful stimuli to the cancer cells.</p>
Fumiyoshi Okano +13 more
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Figure S4 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>CAPRIN-1 expression following EMT induction.</p>
Fumiyoshi Okano +13 more
+4 more sources
Figure S1 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>Anti-CAPRIN-1 antibodies</p>
Fumiyoshi Okano +13 more
+4 more sources