Results 91 to 100 of about 71,965 (172)
A Liquid Crystal Model of Viral DNA Encapsidation
, 2017 A liquid crystal continuum modeling framework for icosahedra bacteriophage viruses is developed and tested. The main assumptions of the model are the chromonic columnar hexagonal structure of confined DNA, the high resistance to bending and the phase ...
Arsuaga, Javier +3 more
core
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]
, 2015 Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston +5 more
core
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus (rAAV) is a widely used delivery vehicle in gene therapy. A scalable production technology is essential for its wide clinical applications. We have taken a synthetic biology approach to generate HEK293‐based cell lines which harbor integrated genetic elements encoding essential AAV and adenoviral helper ...
Han‐Jung Kuo +6 more
wiley +1 more source
Nanoindentation of virus capsids in a molecular model
, 2010 A molecular-level model is used to study the mechanical response of empty cowpea chlorotic mottle virus (CCMV) and cowpea mosaic virus (CPMV) capsids. The model is based on the native structure of the proteins that consitute the capsids and is described ...
Allen M. P. +2 more
core +1 more source
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source
, 2015 Norovirus is one of the most common causes of acute viral gastroenteritis. The virus is spread via the fecal-oral route, most commonly from infected food and water, but several outbreaks have originated from contamination of surfaces with infectious ...
Keevil, C William +2 more
core +1 more source
Antibacterial and antiviral activity of a highly efficient electrospun r‐PET nanofiber
The Canadian Journal of Chemical Engineering, EarlyView.Abstract Since the COVID‐19 pandemic, the emergence of clean air has increased interest in developing antimicrobial air filters, targeting sterilization and public health concerns. Nanofibers are a promising approach due to their high efficiency in air filtration, while nanoparticles adhered to the fibre surfaces can improve safety due to the biocidal ...
Karine Machry +8 more
wiley +1 more source
ChemMedChem, EarlyView.The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska +5 more
wiley +1 more source
New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity
ChemMedChem, EarlyView.A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti +13 more
wiley +1 more source
Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials
Exploration, EarlyView.Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu +4 more
wiley +1 more source