Results 91 to 100 of about 298,386 (364)

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Molecular Evolution of the RNA-Dependent RNA Polymerase and Capsid Genes of Human Norovirus Genotype GII.2 in Japan during 2004–2015

Frontiers in Microbiology, 2017
The RNA-dependent RNA polymerase (RdRp) and capsid (VP1) genes of 51 GII.2 human norovirus (HuNoV) strains collected during the period of 2004–2015 in Japan were analyzed. Full-length analyses of the genes were performed using next-generation sequencing.
Kazuhiko Katayama, Hirokazu Kimura, Hirokazu Kimura, Fuminori Mizukoshi, Koo Nagasawa, Yen H. Doan, Kei Haga, Shima Yoshizumi, Yo Ueki, Michiyo Shinohara, Mariko Ishikawa, Naomi Sakon, Naoki Shigemoto, Reiko Okamoto-Nakagawa, Akie Ochi, Koichi Murakami, Akihide Ryo, Yoshiyuki Suzuki   +17 more
doaj   +1 more source

The role of packaging sites in efficient and specific virus assembly

, 2015
During the lifecycle of many single-stranded RNA viruses, including many human pathogens, a protein shell called the capsid spontaneously assembles around the viral genome. Understanding the mechanisms by which capsid proteins selectively assemble around
Hagan, M. F., Perlmutter, J. D.
core   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Structures of pseudorabies virus capsids

Nature Communications, 2022
AbstractPseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and is responsible for significant economic losses in the swine industry. Recent data points to human viral encephalitis caused by PRV infection, suggesting that PRV may be able to overcome the species barrier to infect humans.
Guosong Wang, Zhenghui Zha, Pengfei Huang, Hui Sun, Yang Huang, Maozhou He, Tian Chen, Lina Lin, Zhenqin Chen, Zhibo Kong, Yuqiong Que, Tingting Li, Ying Gu, Hai Yu, Jun Zhang, Qingbing Zheng, Yixin Chen, Shaowei Li, Ningshao Xia   +18 more
openaire   +3 more sources

Ocular Inflammatory Response to Intravitreal Injection of Adeno-Associated Virus Vector: Relative Contribution of Genome and Capsid

Human Gene Therapy, 2019
Both subretinal dosing and intravitreal (IVT) dosing of adeno-associated virus (AAV) in higher species induce mild and transient inflammatory responses that increase with dose.
A. Timmers, J. Newmark, H. Turunen, Tanaz Farivar, Jilin Liu, Chunjuan Song, G. Ye, Steven Pennock, C. Gaskin, D. R. Knop, M. Shearman   +10 more
semanticscholar   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

Fluorescence Correlation Spectroscopy Analysis of Effect of Molecular Crowding on Self-Assembly of β-Annulus Peptide into Artificial Viral Capsid [PDF]

, 2021
Risako Kobayashi, Hiroshi Inaba, Kazunori Matsuura   +2 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source