Results 111 to 120 of about 71,965 (172)

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, EarlyView.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Occurrence and integrated control of major rice diseases in China

New Plant Protection, EarlyView.
Rice is constantly under threat from a variety of pathogens. This review highlights the major diseases affecting rice in China, including three fungal diseases, two bacterial diseases, two viral diseases, and one nematode. The review also proposes future directions for an integrated approach to control these significant rice diseases.
Ruyi Wang, Zhiyuan Ji, Yanjun Kou, Xiuling Yang, Wenkun Huang, Zongtao Sun, Shimin Zuo, Zhiqiang Li, Yehui Xiong, Yiwen Deng, Xueping Zhou, Guo‐Liang Wang, Jie Liu, Yuese Ning   +13 more
wiley   +1 more source

Clinical characteristics and risk factors of severe bocavirus‐positive pneumonia in children and a literature review

Pediatric Discovery, EarlyView.
The study explored the clinical characteristics and risk factors of HBoV‐positive severe pneumonia in children. These findings indicate that HBoV can be identified in respiratory samples from children with severe pneumonia, denoting its role as a viral pathogen in hospitalized children with this condition.
Jing Liao, Zhongying Yang, Yu He, Jianhua Wei, Luo Ren, Enmei Liu, Na Zang   +6 more
wiley   +1 more source

Complementarity between Orius predators improves control of foliar and flower pests

Pest Management Science, EarlyView.
Orius predators are commonly used against thrips in many crops. Certain species are suggested to be more effective against flower pests, while others may control effectively foliar pests. Here, we show that Orius species combinations may complement each other and effectively control both flower and foliar pests on gerbera.
Angelos Mouratidis, Sophie Le Hesran, Marcel Dicke, Gerben J Messelink   +3 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A71 Challenge

Phytotherapy Research, EarlyView.
Pterostilbene (Pte) binds to the VP1 hydrophobic pocket of enteroviruses, stabilizing the viral capsid and preventing uncoating and RNA release. In vitro, Pte inactivates virions and impairs viral attachment, entry, and replication. In vivo, oral administration of Pte in hSCARB2‐transgenic mice reduces clinical symptoms and improves survival ...
Kuan‐Ting Chuang, Siao‐Cian Pan, Bor‐Luen Chiang, Shih‐Hsun Chen, Min‐Hsiung Pan, Yu‐Li Chen, Cheng‐Sheng Lin, Chun‐Kai Pan, Jing‐Yi Lin, Yu‐Li Lin   +9 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

On the origin of capsids [PDF]

Nature Reviews Microbiology, 2017
openaire   +2 more sources

Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food

Small, EarlyView.
This review discusses recent advancements in nanoparticle‐based nanosensors for multiplex detection of food contaminants, focusing on toxins and pathogens. It highlights the design principles, sensitivity, and selectivity of these sensors, offering insights into their practical applications for food safety monitoring and inspiring future innovations ...
Yang Zhang, Shipeng Gao, Haoran Li, Tianxi Yang, Kaiyi Zheng, Zhing Ming Guo, Jiyong Shi, Xiaowei Huang, Xiaobo Zou, Pierre Picchetti, Frank Biedermann   +10 more
wiley   +1 more source