Results 141 to 150 of about 298,386 (364)

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

mBio
Human immunodeficiency virus type 1 (HIV-1) capsid, which is the target of the antiviral lenacapavir, protects the viral genome and binds multiple host proteins to influence intracellular trafficking, nuclear import, and integration.
Zachary Ingram, Christopher Kline, Alexandra K. Hughson, Parmit K. Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. Dos Santos, Barbie K. Ganser-Pornillos, Simon C. Watkins, Melissa Kane, Alan N. Engelman, Zandrea Ambrose   +12 more
doaj   +1 more source

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Frontiers in Immunology, 2018
Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In
Xiaolei Pei, Xiaolei Pei, Lauriel Freya Earley, Yi He, Yi He, Xiaojing Chen, Nikita Elexa Hall, Richard Jude Samulski, Richard Jude Samulski, Chengwen Li, Chengwen Li   +10 more
doaj   +1 more source

Genome organization and interaction with capsid protein in a multipartite RNA virus. [PDF]

, 2020
We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV).
Beren, Christian, Chakravarty, Antara, Cui, Yanxiang, Gelbart, William M, Knobler, Charles M, Rao, ALN, Yang, Xue, Zhou, Z Hong   +7 more
core  

A novel platform for engineered AAV-based vaccines

Molecular Therapy: Methods & Clinical Development
Engineering of adeno-associated virus (AAV) capsids allowed for the development of gene therapy vectors with improved tropism and enhanced transduction efficiency.
Sabrina Babutzka, Miranda Gehrke, Anastasia Papadopoulou, Maria Diedrichs-Möhring, Maria Giannaki, Lena Hennis, Bastian Föhr, Cale Kooyman, Andreas Osterman, Evangelia Yannaki, Gerhild Wildner, Hermann Ammer, Stylianos Michalakis   +12 more
doaj   +1 more source

Sensing viruses by mechanical tension of DNA in responsive hydrogels

, 2013
The rapid worldwide spread of severe viral infections, often involving novel modifications of viruses, poses major challenges to our health care systems. This means that tools that can efficiently and specifically diagnose viruses are much needed.
Cherstvy, Andrey G., Metzler, Ralf, Shin, Jaeoh   +2 more
core   +2 more sources

Processing of the intracellular form of the west Nile virus capsid protein by the viral NS2B-NS3 protease: an in vitro study [PDF]

, 1994
Vladimir Yamshchikov, Richard W. Compans
openalex   +1 more source

Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization

Journal of Virology
Human astroviruses (HAstVs) are a leading cause of viral childhood diarrhea that infects nearly every individual during their lifetime. Although human astroviruses are highly prevalent, no approved vaccine currently exists.
Sarah Lanning, Nayeli Aguilar-Hernández, Vitor Hugo B. Serrão, Tomás López, Sara M. O'Rourke, Adam Lentz, Lena Ricemeyer, Rafaela Espinosa, Susana López, Carlos F. Arias, Rebecca M. DuBois   +10 more
doaj   +1 more source

Development of Renal-targeted Vectors Through Combined In Vivo Phage Display and Capsid Engineering of Adenoviral Fibers From Serotype 19p [PDF]

, 2007
Laura Denby, Lorraine M. Work, Dan J. Von Seggern, Eugene Wu, John H. McVey, Stuart A. Nicklin, Andrew H. Baker   +6 more
openalex   +1 more source

Clinical targeting of HIV capsid protein with a long-acting small molecule

Nature, 2020
J. Link, M. Rhee, W. Tse, Jim Zheng, J. R. Somoza, W. Rowe, Rebecca Begley, Anna Chiu, Andrew Mulato, Derek Hansen, Eric Singer, Luong K. Tsai, Rujuta A. Bam, Chien-Hung Chou, E. Canales, Gediminas J. Brizgys, Jennifer R. Zhang, Jiayao Li, M. Graupe, P. Morganelli, Qi Liu, Qiaoyin Wu, R. Halcomb, R. Saito, S. Schroeder, Scott E. Lazerwith, S. Bondy, Debi Jin, Magdeleine Hung, N. Novikov, Xiaohong Liu, A. Villaseñor, C. Cannizzaro, E. Hu, R. Anderson, T. Appleby, B. Lu, J. Mwangi, Albert C Liclican, A. Niedziela-Majka, Giuseppe A. Papalia, Melanie H. Wong, Stephanie A. Leavitt, Yili Xu, David Koditek, G. Stepan, Helen Yu, N. Pagratis, Sheila Clancy, Shekeba Ahmadyar, Terrence Z. Cai, S. Sellers, S. A. Wolckenhauer, J. Ling, C. Callebaut, N. Margot, Renee R. Ram, Yapei Liu, R. Hyland, Gary I. Sinclair, P. Ruane, G. Crofoot, Cheryl Mcdonald, D. Brainard, L. Lad, S. Swaminathan, W. Sundquist, R. Sakowicz, A. Chester, William E. Lee, E. Daar, S. Yant, T. Cihlář   +72 more
semanticscholar   +1 more source

Surfactant‐Enhanced Electrospun Nanofiber Filters for Efficient Viral and Bacterial Inactivation

Journal of Applied Polymer Science, EarlyView.
In this work, electrospun polyacrylonitrile (PAN) nanofibrous filters functionalized with surfactants (CTAB, CPC, and SDS) were developed for air filtration applications. The PAN nanofiber mats enable efficient particulate matter capture while simultaneously providing antimicrobial and antiviral activity against bacteria (E. coli and S.
Edilton N. da Silva, Paulo A. M. Chagas, Gustavo C. da Mata, Felipe A. Lima, Fabiana B. Furtado, Wanderley P. de Oliveira, Rejane M. T. Grotto, Clovis W. O. de Souza, Mônica L. Aguiar, Vádila G. Guerra   +9 more
wiley   +1 more source