Results 11 to 20 of about 174,454 (241)
Determination of AAV Capsid Protein Ratios by Sodium Dodecyl Sulfate Capillary Electrophoresis (CE-SDS)-UV Absorption Method. [PDF]
ElectrophoresisABSTRACT Recombinant adeno‐associated viruses (AAVs) have become a leading platform for in vivo gene therapy. The AAV capsid is assembled from 60 individual protein subunits derived from three overlapping viral proteins (VPs): VP1, VP2, and VP3. The VP's ratio distribution affects the capsid trafficking and transgene expression.
Li Y +10 more
europepmc +2 more sources
Journal of Molecular Cell Biology, 2023 Abstract Lenacapavir, targeting the human immunodeficiency virus type-1 (HIV-1) capsid, is the first-in-class antiretroviral drug recently approved for clinical use. The development of Lenacapavir is attributed to the remarkable progress in our understanding of the capsid protein made during the last few years.
Ian A Taylor, Ariberto Fassati
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HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules [PDF]
Retrovirology, 2021 AbstractThe HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in multiple post-entry processes during viral replication. Many host factors can directly bind to the HIV-1 capsid protein (CA) and either promote or prevent HIV-1 infection.
Akatsuki Saito, Masahiro Yamashita
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A Narrative Review on Current Development and Future Prospects for the Treatment of Dengue Virus Infection [PDF]
Liaquat National Journal of Primary CareIncidences of dengue-virus infection are increasing globally. Around 3.90 billion population is at high risk of infection. There is no cure/ prevention available.
Sheikh Abdul Khaliq +3 more
doaj +1 more source
Viruses, 2023 The hollow protein capsids from a number of different viruses are being considered for multiple biomedical or nanotechnological applications. In order to improve the applied potential of a given viral capsid as a nanocarrier or nanocontainer, specific ...
Miguel Angel Fuertes +5 more
doaj +1 more source
Nanomedicine and Phage Capsids [PDF]
Viruses, 2018 Studies of phage capsids have at least three potential interfaces with nanomedicine. First, investigation of phage capsid states potentially will provide therapies targeted to similar states of pathogenic viruses. Recently detected, altered radius-states of phage T3 capsids include those probably related to intermediate states of DNA injection and DNA ...
Philip Serwer, Elena T. Wright
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eLife, 2023 Communication between distant cells can be mediated by extracellular vesicles (EVs) that deliver proteins and RNAs to recipient cells. Little is known about how EVs are targeted to specific cell types.
Peter H Lee +4 more
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Genetic Code Expansion and Bio-Orthogonal Labeling Reveal Intact HIV-1 Capsids inside the Nucleus
mBio, 2022 Microscopy is one of the few techniques that can directly observe the HIV-1 capsid as it traverses the cell. However, an extrinsic or intrinsic label is needed to facilitate detection and this can perturb capsid behavior. Now, S. Schifferdecker, V. Zila,
Leo C. James
doaj +1 more source
Maturation of Papillomavirus Capsids [PDF]
Journal of Virology, 2005 ABSTRACT The papillomavirus capsid is a nonenveloped icosahedral shell formed by the viral major structural protein, L1. It is known that disulfide bonds between neighboring L1 molecules help to stabilize the capsid. However, the kinetics of inter-L1 disulfide bond formation during particle morphogenesis have not previously been examined.
Christopher B, Buck +4 more
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Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
eLife, 2022 The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stability and uncoating.
Chantal L Márquez +12 more
openaire +5 more sources