Results 11 to 20 of about 298,386 (364)
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
eLife, 2018 The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability from minutes to hours and
Donna L Mallery +10 more
doaj +2 more sources
Critical mechanistic features of HIV-1 viral capsid assembly
bioRxiv, 2022 The maturation of HIV-1 capsid protein (CA) into a cone-shaped lattice encasing the condensed RNA genome is critical for viral infectivity. During HIV-1 maturation, CA can self-assemble into a wide range of capsid morphologies made of ~175-250 hexamers ...
Manish Gupta, A. Pak, G. Voth
semanticscholar +1 more source
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features
Viruses, 2021 The capsid structures of most Adeno-associated virus (AAV) serotypes, already assigned to an antigenic clade, have been previously determined. This study reports the remaining capsid structures of AAV7, AAV11, AAV12, and AAV13 determined by cryo-electron
M. Mietzsch +6 more
semanticscholar +1 more source
Journal of Molecular Cell Biology, 2023 Abstract Lenacapavir, targeting the human immunodeficiency virus type-1 (HIV-1) capsid, is the first-in-class antiretroviral drug recently approved for clinical use. The development of Lenacapavir is attributed to the remarkable progress in our understanding of the capsid protein made during the last few years.
Ian A Taylor, Ariberto Fassati
openaire +2 more sources
Cells and Fugu Response to Capsid of BFNNV Genotype
Viruses, 2023 The nervous necrosis virus (NNV) of the BFNNV genotype is the causative agent of viral encephalopathy and retinopathy (VER) in cold water fishes. Similar to the RGNNV genotype, BFNNV is also considered a highly destructive virus.
Mingguang Mao +5 more
doaj +1 more source
Rotten to the core: antivirals targeting the HIV-1 capsid core
Retrovirology, 2021 The capsid core of HIV-1 is a large macromolecular assembly that surrounds the viral genome and is an essential component of the infectious virus. In addition to its multiple roles throughout the viral life cycle, the capsid interacts with multiple host ...
William M. McFadden +6 more
semanticscholar +1 more source
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor
Science, 2020 Attacking HIV by stabilizing its capsid Current HIV treatments require drugs that must be taken daily, and care would be improved with an effective drug that is long-acting.
S. Bester +18 more
semanticscholar +1 more source
Adeno-associated virus capsid assembly is divergent and stochastic
Nature Communications, 2020 Adeno-associated viruses (AAVs) are increasingly used as gene therapy vectors. AAVs package their genome in a non-enveloped T = 1 icosahedral capsid of ~3.8 megaDalton, consisting of 60 subunits of 3 distinct viral proteins (VPs), which vary only in ...
Tobias P. Wörner +7 more
semanticscholar +1 more source
HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules [PDF]
Retrovirology, 2021 AbstractThe HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in multiple post-entry processes during viral replication. Many host factors can directly bind to the HIV-1 capsid protein (CA) and either promote or prevent HIV-1 infection.
Akatsuki Saito, Masahiro Yamashita
openaire +4 more sources