Results 21 to 30 of about 177,162 (260)
Frontiers in Microbiology, 2019 Pandoraviruses are giant viruses of ameba with 1 μm-long virions. They have an ovoid morphology and are surrounded by a tegument-like structure lacking any capsid protein nor any gene encoding a capsid protein. In this work, we studied the ultrastructure
Djamal Brahim Belhaouari +9 more
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Hepatitis A Virus Capsid Structure [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Hepatitis A virus (HAV) has been enigmatic, evading detailed structural analysis for many years. Its recently determined high-resolution structure revealed an angular surface without the indentations often characteristic of receptor-binding sites. The viral protein 1 (VP1) β-barrel shows no sign of a pocket factor and the amino terminus of VP2 displays
Stuart, D +4 more
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Frontiers in Microbiology, 2017 Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others.
Francisco J. Ibáñez +7 more
doaj +1 more source
HIV-1 Capsid Core: A Bullet to the Heart of the Target Cell
Frontiers in Microbiology, 2021 The first step of the intracellular phase of retroviral infection is the release of the viral capsid core in the cytoplasm. This structure contains the viral genetic material that will be reverse transcribed and integrated into the genome of infected ...
Elenia Toccafondi +2 more
doaj +1 more source
Mechanical properties of viral capsids [PDF]
Physical Review E, 2005 12 ...
Zandi, Roya, Reguera, D. (David)
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HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules [PDF]
Retrovirology, 2021 AbstractThe HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in multiple post-entry processes during viral replication. Many host factors can directly bind to the HIV-1 capsid protein (CA) and either promote or prevent HIV-1 infection.
Akatsuki Saito, Masahiro Yamashita
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Viruses, 2020 The assembly of picornavirus capsids proceeds through the stepwise oligomerization of capsid protein subunits and depends on interactions between critical residues known as hotspots.
Nicole Upfold +3 more
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Use of Capsid Integrity-qPCR for Detecting Viral Capsid Integrity in Wastewater
Viruses, 2023 Quantifying viruses in wastewater via RT-qPCR provides total genomic data but does not indicate the virus capsid integrity or the potential risk for human infection. Assessing virus capsid integrity in sewage is important for wastewater-based surveillance, since discharged effluent may pose a public health hazard.
Jessica L. Kevill +5 more
openaire +3 more sources
Molecular Therapy: Methods & Clinical Development, 2022 Prescreening of participants in clinical trials that use adeno-associated virus (AAV) vectors is required to identify naive participants, as preexisting neutralizing antibodies can limit the efficacy of AAV gene therapies.
Matthew R. Gardner +6 more
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Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source