Results 11 to 20 of about 214,858 (192)

Capsid

, 2011
Capsid is a water-jet cut optiwhite glass and perspex artwork suspended in a grid-like formation by vertical nylon wires, created in an attempt to visualize a viral capsid in the process of self-assembly or ...
Rennie, Colin
core   +8 more sources

Arthritogenic Alphavirus Capsid Protein

Life, 2021
In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial
Shambhavi Rao, Adam Taylor
doaj   +2 more sources

The capsid revolution

Journal of Molecular Cell Biology, 2023
Abstract Lenacapavir, targeting the human immunodeficiency virus type-1 (HIV-1) capsid, is the first-in-class antiretroviral drug recently approved for clinical use. The development of Lenacapavir is attributed to the remarkable progress in our understanding of the capsid protein made during the last few years.
Ian A Taylor, Ariberto Fassati
openaire   +3 more sources

Baseline Lenacapavir Resistance and Capsid Variability in Bulgaria: A Next-Generation Sequencing Study of Newly Diagnosed HIV-1 Infections. [PDF]

Pathogens
Lenacapavir, the first approved HIV-1 capsid inhibitor, is now being introduced for both treatment and pre-exposure prophylaxis, yet the capsid-coding region lies outside the pol fragment examined in routine genotypic resistance testing, and baseline ...
Alexiev I, Partsuneva A, Dimitrova R, Kostadinova A, Gancheva A, Grigorova L, Stoyanova K, Nikolova M, Emilova R, Yancheva N, Strashimirov D, Baltadzhiev I, Doychinova T, Parusheva P, Todorova I.   +14 more
europepmc   +2 more sources

Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders

Langmuir, 2020
The human immunodeficiency virus (HIV) capsid is a cone-shaped capsule formed from the viral capsid protein (CA), which is arranged into a lattice of hexamers and pentamers. The capsid comprises multiple binding interfaces for the recruitment of host proteins and macromolecules used by the virus to establish infection.
Lau, D, Walsh, JC, Mousapasandi, A, Ariotti, N, Shah, VB, Turville, S, Jacques, DA, Böcking, T   +7 more
openaire   +6 more sources

Control of Capsid Transformations during Reovirus Entry

Viruses, 2021
Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate.
Stephanie L. Gummersheimer, Anthony J. Snyder, Pranav Danthi   +2 more
doaj   +1 more source

The Role of Capsid in HIV-1 Nuclear Entry

Viruses, 2021
HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán, Eve R. Caroe, Genevieve C. R. Barr, Kate N. Bishop   +3 more
doaj   +1 more source

Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production

Biomolecules, 2021
Previously, a designed ankyrin repeat protein, AnkGAG1D4, was generated for intracellular targeting of the HIV-1 capsid domain. The efficiency was satisfactory in interfering with the HIV assembly process.
Kanokporn Sornsuwan, Weeraya Thongkhum, Thanathat Pamonsupornwichit, Tanawan Samleerat Carraway, Suthinee Soponpong, Supachai Sakkhachornphop, Chatchai Tayapiwatana, Umpa Yasamut   +7 more
doaj   +1 more source

Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity

mBio, 2022
The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence in ...
Ryan C. Burdick, Claire Deleage, Alice Duchon, Jacob D. Estes, Wei-Shau Hu, Vinay K. Pathak   +5 more
doaj   +1 more source

TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection

Viruses, 2022
The core of HIV-1 viruses bearing the capsid change N74D (HIV-1-N74D) do not bind the human protein CPSF6. In primary human CD4+ T cells, HIV-1-N74D viruses exhibit an infectivity defect when compared to wild-type.
Anastasia Selyutina, Lacy M. Simons, Karen A. Kirby, Angel Bulnes-Ramos, Pan Hu, Stefan G. Sarafianos, Judd F. Hultquist, Felipe Diaz-Griffero   +7 more
doaj   +1 more source