Results 31 to 40 of about 249,247 (291)

Osmotic pressure: resisting or promoting DNA ejection from phage [PDF]

, 2008
Recent in vitro experiments have shown that DNA ejection from bacteriophage can be partially stopped by surrounding osmotic pressure when ejected DNA is digested by DNase I on the course of ejection.
Castelnovo, Martin, Evilevitch, Alex,, Jeembaeva, Meerim,, Larsson, Frida, Lund University.   +4 more
core   +3 more sources

The In Silico Prediction of Hotspot Residues that Contribute to the Structural Stability of Subunit Interfaces of a Picornavirus Capsid

Viruses, 2020
The assembly of picornavirus capsids proceeds through the stepwise oligomerization of capsid protein subunits and depends on interactions between critical residues known as hotspots.
Nicole Upfold, Caroline Ross, Özlem Tastan Bishop, Caroline Knox   +3 more
doaj   +1 more source

Proton-Linked Dimerization of a Retroviral Capsid Protein Initiates Capsid Assembly [PDF]

Structure, 2009
In mature retroviral particles, the capsid protein (CA) forms a shell encasing the viral replication complex. Human immunodeficiency virus (HIV) CA dimerizes in solution, through its C-terminal domain (CTD), and this interaction is important for capsid assembly.
Bailey, Graham, Hyun, Jae, Mitra, Alok, Kingston, Richard   +3 more
openaire   +3 more sources

Radial distribution of RNA genome packaged inside spherical viruses

, 2008
The problem of RNA genomes packaged inside spherical viruses is studied. The viral capsid is modeled as a hollowed sphere. The attraction between RNA molecules and the inner viral capsid is assumed to be non-specific and occurs at the inner capsid ...
J. Johnson, P.-G. de Gennes, Se Il Lee, Toan T. Nguyen   +3 more
core   +1 more source

Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms [PDF]

Cell Host & Microbe, 2019
The HIV-1 capsid is an ordered protein shell that houses the viral genome during early infection. Its expansive surface consists of an ordered and interfacing array of capsid protein hexamers and pentamers that are recognized by numerous cellular proteins. Many of these proteins recognize specific, assembled capsid interfaces not present in unassembled
Brady J, Summers, Katherine M, Digianantonio, Sarah S, Smaga, Pei-Tzu, Huang, Kaifeng, Zhou, Eva E, Gerber, Wei, Wang, Yong, Xiong   +7 more
openaire   +2 more sources

High concordance of ELISA and neutralization assays allows for the detection of antibodies to individual AAV serotypes

Molecular Therapy: Methods & Clinical Development, 2022
Prescreening of participants in clinical trials that use adeno-associated virus (AAV) vectors is required to identify naive participants, as preexisting neutralizing antibodies can limit the efficacy of AAV gene therapies.
Matthew R. Gardner, Desiree E. Mendes, Claudia P. Muniz, José M. Martinez-Navio, Sebastian P. Fuchs, Guangping Gao, Ronald C. Desrosiers   +6 more
doaj   +1 more source

Role of Genome in the Formation of Conical Retroviral Shells

, 2016
Human immunodeficiency virus (HIV) capsid proteins spontaneously assemble around the genome into a protective protein shell called the capsid, which can take on a variety of shapes broadly classified as conical, cylindrical and irregular. The majority of
Erdemci-Tandogan, Gonca, van der Schoot, Paul, Wagner, Jef, Zandi, Roya   +3 more
core   +2 more sources

Force steps during viral DNA packaging ? [PDF]

, 2003
Biophysicists and structural biologists increasingly acknowledge the role played by the mechanical properties of macromolecules as a critical element in many biological processes.
Alberts, Boal, Bray, Bustamante, Cerritelli, Doi, Earnshaw, Earnshaw, Freund, Goldstein, Jané Kondev, Kindt, Lo, Meyers, Odijk, Parsegian, Prashant K. Purohit, Ptashne, Purohit, Raspaud, Rau, Rice, Riemer, Rob Phillips, Rosakis, Smith, Tao, Wang, Widom, Wikoff   +29 more
core   +2 more sources

Host-driven evolution of PCV2: insights into genetic diversity and adaptation

Frontiers in Immunology
IntroductionsPorcine circovirus type 2 (PCV2) is a significant pathogen in swine, exhibiting notable genetic and phenotypic diversity. This study explores the evolutionary mechanisms influencing PCV2 variability, emphasizing the role of viral features ...
Giovanni Franzo, Matteo Legnardi, Francesca Poletto, Riccardo Baston, Mattia Cecchinato, Michele Drigo, Claudia Maria Tucciarone   +6 more
doaj   +1 more source

Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines

Viruses, 2020
Capsid-like particles (CLPs) are multimeric, repetitive assemblies of recombinant viral capsid proteins, which are highly immunogenic due to their structural similarity to wild-type viruses.
Kara-Lee Aves, Louise Goksøyr, Adam F. Sander   +2 more
doaj   +1 more source