Results 21 to 30 of about 174,454 (241)
Frontiers in Microbiology, 2019 Pandoraviruses are giant viruses of ameba with 1 μm-long virions. They have an ovoid morphology and are surrounded by a tegument-like structure lacking any capsid protein nor any gene encoding a capsid protein. In this work, we studied the ultrastructure
Djamal Brahim Belhaouari +9 more
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Mechanical properties of viral capsids [PDF]
Physical Review E, 2005 12 ...
Zandi, Roya, Reguera, D. (David)
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Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Frontiers in Microbiology, 2017 Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others.
Francisco J. Ibáñez +7 more
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HIV-1 Capsid Core: A Bullet to the Heart of the Target Cell
Frontiers in Microbiology, 2021 The first step of the intracellular phase of retroviral infection is the release of the viral capsid core in the cytoplasm. This structure contains the viral genetic material that will be reverse transcribed and integrated into the genome of infected ...
Elenia Toccafondi +2 more
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Hepatitis A Virus Capsid Structure [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Hepatitis A virus (HAV) has been enigmatic, evading detailed structural analysis for many years. Its recently determined high-resolution structure revealed an angular surface without the indentations often characteristic of receptor-binding sites. The viral protein 1 (VP1) β-barrel shows no sign of a pocket factor and the amino terminus of VP2 displays
Stuart, D +4 more
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Viruses, 2020 The assembly of picornavirus capsids proceeds through the stepwise oligomerization of capsid protein subunits and depends on interactions between critical residues known as hotspots.
Nicole Upfold +3 more
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Proton-Linked Dimerization of a Retroviral Capsid Protein Initiates Capsid Assembly [PDF]
Structure, 2009 In mature retroviral particles, the capsid protein (CA) forms a shell encasing the viral replication complex. Human immunodeficiency virus (HIV) CA dimerizes in solution, through its C-terminal domain (CTD), and this interaction is important for capsid assembly.
Bailey, Graham +3 more
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Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms [PDF]
Cell Host & Microbe, 2019 The HIV-1 capsid is an ordered protein shell that houses the viral genome during early infection. Its expansive surface consists of an ordered and interfacing array of capsid protein hexamers and pentamers that are recognized by numerous cellular proteins. Many of these proteins recognize specific, assembled capsid interfaces not present in unassembled
Brady J, Summers +7 more
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Molecular Therapy: Methods & Clinical Development, 2022 Prescreening of participants in clinical trials that use adeno-associated virus (AAV) vectors is required to identify naive participants, as preexisting neutralizing antibodies can limit the efficacy of AAV gene therapies.
Matthew R. Gardner +6 more
doaj +1 more source