TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
Nature Communications, 2020 The tripartite-motif protein, TRIM5α, is an innate immune sensor that potently restricts retrovirus infection by binding to human immunodeficiency virus capsids.
A. Yu +5 more
semanticscholar +1 more source
Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein.
Gastroenterology, 2018 BACKGROUND & AIMS Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. Approximately 2 billion people live in areas endemic for HEV and are at risk of infection.
C. Montpellier +19 more
semanticscholar +1 more source
Minimum energy paths for conformational changes of viral capsids [PDF]
, 2017 In this work we study how a viral capsid can change conformation using techniques of Large Deviations Theory for stochastic differential equations. The viral capsid is a model of a complex system in which many units - the proteins forming the capsomers -
Cermelli, Paolo +2 more
core +2 more sources
In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. [PDF]
, 2016 Packaging of the genome into a protein capsid and its subsequent delivery into a host cell are two fundamental processes in the life cycle of a virus. Unlike double-stranded DNA viruses, which pump their genome into a preformed capsid, single-stranded ...
Dai, Xinghong +6 more
core +1 more source
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
core +2 more sources
Radial distribution of RNA genome packaged inside spherical viruses
, 2008 The problem of RNA genomes packaged inside spherical viruses is studied. The viral capsid is modeled as a hollowed sphere. The attraction between RNA molecules and the inner viral capsid is assumed to be non-specific and occurs at the inner capsid ...
J. Johnson +3 more
core +1 more source
Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
, 2008 Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric +4 more
core +3 more sources
Role of Genome in the Formation of Conical Retroviral Shells
, 2016 Human immunodeficiency virus (HIV) capsid proteins spontaneously assemble around the genome into a protective protein shell called the capsid, which can take on a variety of shapes broadly classified as conical, cylindrical and irregular. The majority of
Erdemci-Tandogan, Gonca +3 more
core +2 more sources
Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism [PDF]
, 2013 The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process.
Bakker, S.E. +10 more
core +2 more sources
Electrostatic theory of viral self-assembly: a toy model
, 2007 Viruses self-assemble from identical capsid proteins and their genome consisting, for example, of a long single stranded (ss) RNA. For a big class of T = 3 viruses capsid proteins have long positive N-terminal tails.
Adolph +17 more
core +1 more source