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Liquid Viruses by Nanoscale Engineering of Capsid Surfaces [PDF]
Advanced Materials, 2012 Surface engineering of plant virus capsids via cationization (1) and stoichiometric coupling of a polymer surfactant coronal layer (2) produces a highly concentrated, solvent-free liquid virus at 28 °C. These ionic bionanoconstructs are viscoelastic, retain plant infectivity and can be dispersed in a range of organic solvents for aerosol delivery.
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Journal of Biomedical Nanotechnology, 2015
Virus capsids have evolved to protect the genome sequestered in their interior from harsh environmental conditions, and to deliver it safely and precisely to the host cell of choice. This characteristic makes them naturally perfect containers for delivering therapeutic molecules to specific locations.
Manidipa Banerjee
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Virus capsids have evolved to protect the genome sequestered in their interior from harsh environmental conditions, and to deliver it safely and precisely to the host cell of choice. This characteristic makes them naturally perfect containers for delivering therapeutic molecules to specific locations.
Manidipa Banerjee
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Production and applications of engineered viral capsids
Applied Microbiology and Biotechnology, 2014As biological agents, viruses come in an astounding range of sizes, with varied shapes and surface morphologies. The structures of viral capsids are generally assemblies of hundreds of copies of one or a few proteins which can be harnessed for use in a wide variety of applications in biotechnology, nanotechnology, and medicine. Despite their complexity,
Jeff, Glasgow, Danielle, Tullman-Ercek
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Machine-learning-guided Directed Evolution for AAV Capsid Engineering
Current Pharmaceutical DesignAbstract: Target gene delivery is crucial to gene therapy. Adeno-associated virus (AAV) has emerged as a primary gene therapy vector due to its broad host range, long-term expression, and low pathogenicity. However, AAV vectors have some limitations, such as immunogenicity and insufficient targeting.
Hairui Suo
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Engineering the AAV capsid to optimize vector–host-interactions
Current Opinion in Pharmacology, 2015Adeno-associated viral (AAV) vectors are the most widely used delivery system for in vivo gene therapy. Vectors developed from natural AAV isolates achieved clinical benefit for a number of patients suffering from monogenetic disorders. However, high vector doses were required and the presence of pre-existing neutralizing antibodies precluded a number ...
Hildegard, Büning +4 more
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Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen
PLoS Pathogens, 2013 Foot-and-mouth disease remains a major plague of livestock and outbreaks are often economically catastrophic. Current inactivated virus vaccines require expensive high containment facilities for their production and maintenance of a cold-chain for their activity. We have addressed both of these major drawbacks.
Elizabeth E Fry +2 more
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Genetic Engineering of AAV Capsid Gene for Gene Therapy Application
Current Gene Therapy, 2020Adeno-associated virus (AAV) is a promising vector for in vivo gene therapy because of its excellent safety profile and ability to mediate stable gene expression in human subjects. However, there are still numerous challenges that need to be resolved before this gene delivery vehicle is used in clinical applications, such as the inability of AAV to ...
Yunbo, Liu, Xu, Zhang, Lin, Yang
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Engineering Thermal Stability in RNA Phage Capsids via Disulphide Bonds
Journal of Nanoscience and Nanotechnology, 2005The RNA bacteriophages, a group that includes phages Qbeta and MS2, have a number of potential bionanotechnological applications, including cell specific drug delivery and as substrates for the formation of novel materials. Despite extensive sequence identity between their coat protein subunits, and an almost identical three-dimensional fold, Qbeta and
Alison E, Ashcroft +5 more
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Guest Sequence Can Influence RNA Encapsulation by an Engineered Cationic Protein Capsid
Biochemistry, 2020Specific encapsulation of RNA in a cell is a challenging molecular recognition problem that has important implications for virology and drug delivery. An engineered variant of the Aquifex aeolicus lumazine synthase capsid that possesses a positively supercharged interior (AaLS-pos) has previously been shown to encapsulate a mixture of cellular RNAs in ...
Jiannan Fu, Kenneth J. Woycechowsky
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At the cutting edge of AAV capsid engineering
Cell and Gene Therapy Insights, 2023Eric Kelsic, Adrian Veres
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