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Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve
Gene TherapyGenetic diseases such as Neurofibromatosis type 1 (NF1) and Charcot-Marie Tooth disease involve Schwann cells (SCs) associated with peripheral nerves. Gene therapy using adeno-associated virus (AAV) vector mediated gene delivery is a promising strategy to treat these diseases.
Edwina Abou Haidar +18 more
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Capsid Engineering of Adenovirus Vectors: Overcoming Early Vector–Host Interactions for Therapy
Human Gene Therapy, 2017Adenovirus-based vectors comprise the most frequently used vector type in clinical studies to date. Both intense lab research and insights from the clinical trials reveal the importance of a comprehensive understanding of vector–host interactions.
Claudia, Hagedorn, Florian, Kreppel
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Construction of nanoscale supramolecular complexes using engineered protein capsids
2018Most proteins assemble into oligomeric complexes. These supramolecular associations may confer many advantages to the substituents. Polyhedral capsids represent a common, highly symmetric nanoscale architecture in which multiple subunits self-assemble to form a hollow three-dimensional surface which often serve as molecular containers or platforms for ...
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In Vivo Capsid Engineering of Bacteriophages for Oriented Surface Conjugation
ACS Applied Bio Materials, 2022Julie M Goddard +2 more
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Cone-shaped HIV-1 capsids are transported through intact nuclear pores
Cell, 2021Barbara Müller +2 more
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ADENO-ASSOCIATED VIRUS WITH ENGINEERED CAPSID
2021REID CHRISTOPHER A, CHENG ZE
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