Results 221 to 230 of about 31,732 (250)

Guest Sequence Can Influence RNA Encapsulation by an Engineered Cationic Protein Capsid

Biochemistry, 2020
Specific encapsulation of RNA in a cell is a challenging molecular recognition problem that has important implications for virology and drug delivery. An engineered variant of the Aquifex aeolicus lumazine synthase capsid that possesses a positively supercharged interior (AaLS-pos) has previously been shown to encapsulate a mixture of cellular RNAs in ...
Jiannan Fu, Kenneth J. Woycechowsky
openaire   +2 more sources

At the cutting edge of AAV capsid engineering

Cell and Gene Therapy Insights, 2023
Eric Kelsic, Adrian Veres
openaire   +1 more source

Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve

Gene Therapy
Genetic diseases such as Neurofibromatosis type 1 (NF1) and Charcot-Marie Tooth disease involve Schwann cells (SCs) associated with peripheral nerves. Gene therapy using adeno-associated virus (AAV) vector mediated gene delivery is a promising strategy to treat these diseases.
Edwina Abou Haidar, Shilpa Prabhakar, Pike See Cheah, Killian S. Hanlon, Paula Espinoza, Adam V. Crain, Nikita Patel, Greta W. Radcliff, Ming Cheng, Iván Coto Hernández, Steven Minderler, Demitri de la Cruz, Carrie Ng, Cintia Carla da Hora, Alain Charest, Anat Stemmer-Rachamimov, Nate Jowett, Xandra O. Breakefield, Casey A. Maguire   +18 more
openaire   +2 more sources

In Vivo Encapsulation of Nucleic Acids Using an Engineered Nonviral Protein Capsid

Journal of the American Chemical Society, 2012
In Nature, protein capsids function as molecular containers for a wide variety of molecular cargoes. Such containers have great potential for applications in nanotechnology, which often require encapsulation of non-native guest molecules. Charge complementarity represents a potentially powerful strategy for engineering novel encapsulation systems.
Seth, Lilavivat, Debosmita, Sardar, Subrata, Jana, Geoffrey C, Thomas, Kenneth J, Woycechowsky   +4 more
openaire   +2 more sources

ADENO-ASSOCIATED VIRUS WITH ENGINEERED CAPSID

2023
CHENG ZE, HOEY TIMOTHY C, REID CHRISTOPHER A   +2 more
openaire   +5 more sources

In Vivo Capsid Engineering of Bacteriophages for Oriented Surface Conjugation

ACS Applied Bio Materials, 2022
Julie M Goddard, Sam Nugen, Qingmin Chen   +2 more
exaly  

Capsid-Engineering for Central Nervous System-Directed Gene Therapy with Adeno-Associated Virus Vectors

Human Gene Therapy, 2021
Hildegard Büning
exaly  

AAV Capsid Engineering: Zooming in on the Target

Human Gene Therapy, 2017
openaire   +3 more sources

Construction of nanoscale supramolecular complexes using engineered protein capsids

2018
Most proteins assemble into oligomeric complexes. These supramolecular associations may confer many advantages to the substituents. Polyhedral capsids represent a common, highly symmetric nanoscale architecture in which multiple subunits self-assemble to form a hollow three-dimensional surface which often serve as molecular containers or platforms for ...
openaire   +1 more source

Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species

Cell, 2021
Alexandra Stanton, Alan H Beggs, Behzad Moghadaszadeh   +2 more
exaly