Results 211 to 220 of about 31,732 (250)

Storage conditions and antiviral efficacy of yeast-derived vacuoles on T4 virus. [PDF]

Microbiol Spectr
Kim T, Jeong J-H, Kim Y-H, Min J.
europepmc   +1 more source

Engineered AAV Capsids with Enhanced Extracellular Vesicle Loading via Rational Design and Directed Evolution

Vorobieva I, Luchner M, Friedrichsen H, Makkar R, Chester S, Haughton E, Conceiao M, Steel H, Sanders SJ, Wood MP, Gupta D.   +10 more
europepmc   +1 more source

Liquid Viruses by Nanoscale Engineering of Capsid Surfaces [PDF]

Advanced Materials, 2012
Surface engineering of plant virus capsids via cationization (1) and stoichiometric coupling of a polymer surfactant coronal layer (2) produces a highly concentrated, solvent-free liquid virus at 28 °C. These ionic bionanoconstructs are viscoelastic, retain plant infectivity and can be dispersed in a range of organic solvents for aerosol delivery.
Stephen Mann, Avinash Patil, David Evans   +2 more
exaly   +5 more sources

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Production and applications of engineered viral capsids

Applied Microbiology and Biotechnology, 2014
As biological agents, viruses come in an astounding range of sizes, with varied shapes and surface morphologies. The structures of viral capsids are generally assemblies of hundreds of copies of one or a few proteins which can be harnessed for use in a wide variety of applications in biotechnology, nanotechnology, and medicine. Despite their complexity,
Jeff, Glasgow, Danielle, Tullman-Ercek
openaire   +2 more sources

Genetic Engineering of AAV Capsid Gene for Gene Therapy Application

Current Gene Therapy, 2020
Adeno-associated virus (AAV) is a promising vector for in vivo gene therapy because of its excellent safety profile and ability to mediate stable gene expression in human subjects. However, there are still numerous challenges that need to be resolved before this gene delivery vehicle is used in clinical applications, such as the inability of AAV to ...
Yunbo, Liu, Xu, Zhang, Lin, Yang
exaly   +3 more sources

Machine-learning-guided Directed Evolution for AAV Capsid Engineering

Current Pharmaceutical Design
Abstract: Target gene delivery is crucial to gene therapy. Adeno-associated virus (AAV) has emerged as a primary gene therapy vector due to its broad host range, long-term expression, and low pathogenicity. However, AAV vectors have some limitations, such as immunogenicity and insufficient targeting.
Hairui Suo
exaly   +3 more sources

Engineering the AAV capsid to optimize vector–host-interactions

Current Opinion in Pharmacology, 2015
Adeno-associated viral (AAV) vectors are the most widely used delivery system for in vivo gene therapy. Vectors developed from natural AAV isolates achieved clinical benefit for a number of patients suffering from monogenetic disorders. However, high vector doses were required and the presence of pre-existing neutralizing antibodies precluded a number ...
Hildegard, Büning, Anke, Huber, Liang, Zhang, Nadja, Meumann, Ulrich, Hacker   +4 more
openaire   +2 more sources

Engineering Virus Capsids Into Biomedical Delivery Vehicles: Structural Engineering Problems in Nanoscale

Journal of Biomedical Nanotechnology, 2015
Virus capsids have evolved to protect the genome sequestered in their interior from harsh environmental conditions, and to deliver it safely and precisely to the host cell of choice. This characteristic makes them naturally perfect containers for delivering therapeutic molecules to specific locations.
Saumya, Bajaj, Manidipa, Banerjee
openaire   +2 more sources

Engineering Thermal Stability in RNA Phage Capsids via Disulphide Bonds

Journal of Nanoscience and Nanotechnology, 2005
The RNA bacteriophages, a group that includes phages Qbeta and MS2, have a number of potential bionanotechnological applications, including cell specific drug delivery and as substrates for the formation of novel materials. Despite extensive sequence identity between their coat protein subunits, and an almost identical three-dimensional fold, Qbeta and
Alison E, Ashcroft, Hugo, Lago, Jacyara M B, Macedo, Wilf T, Horn, Nicola J, Stonehouse, Peter G, Stockley   +5 more
openaire   +2 more sources

Capsid Engineering of Adenovirus Vectors: Overcoming Early Vector–Host Interactions for Therapy

Human Gene Therapy, 2017
Adenovirus-based vectors comprise the most frequently used vector type in clinical studies to date. Both intense lab research and insights from the clinical trials reveal the importance of a comprehensive understanding of vector–host interactions.
Claudia Hagedorn
exaly   +3 more sources